Morphine responsiveness to thermal pain stimuli is aging-associated and mediated by dopamine D1 and D3 receptor interactions

Highlights • Pain withdrawal reflexes are age-dependent and dopamine D3 receptor-mediated. • Block of dopamine D1 receptor in young D3KO animals mimics aged wild-type controls. • In old animals, dopamine D1 receptor block can mimic analgesic effects of morphine.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2017-05, Vol.349, p.87-97
Hauptverfasser:	Samir, Sophia, Yllanes, Alexander P, Lallemand, Perrine, Brewer, Kori L, Clemens, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Aging - physiology animal model Animals chronic pain Dopamine - metabolism dopamine receptor interactions Mice, Knockout Morphine - pharmacology morphine tolerance Neurology Pain Receptors, Dopamine D1 - drug effects Receptors, Dopamine D3 - drug effects Reflex - drug effects Reflex - physiology spinal cord Spinal Cord - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Pain withdrawal reflexes are age-dependent and dopamine D3 receptor-mediated. • Block of dopamine D1 receptor in young D3KO animals mimics aged wild-type controls. • In old animals, dopamine D1 receptor block can mimic analgesic effects of morphine.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2017.02.042