A case of membranoproliferative glomerulonephritis developed over twenty years with three different findings of renal pathology
A 31-year-old woman with proteinuria, hypocomplementemia, rheumatoid factor, and high serum polyclonal IgM concentration was admitted to our hospital for renal biopsy. She had a past history of two renal biopsies. When she was 12 years old, she developed proteinuria, microscopic hematuria, and hypoc...
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description | A 31-year-old woman with proteinuria, hypocomplementemia, rheumatoid factor, and high serum polyclonal IgM concentration was admitted to our hospital for renal biopsy. She had a past history of two renal biopsies. When she was 12 years old, she developed proteinuria, microscopic hematuria, and hypocomplementemia. She was diagnosed as having ‘IgM nephropathy’ based on minor glomerular abnormalities as determined by light microscopy and IgM and C3 deposition in the mesangial region by immunofluorescence microscopy at the first biopsy. Despite corticosteroid treatment, her proteinuria did not improve and she discontinued regular outpatient checkups. When she was 29 years old and pregnant, she developed preeclampsia and, after delivery, a second renal biopsy was implemented. She was diagnosed as having progressed ‘IgM nephropathy’ with endotheliosis induced by preeclampsia. She was treated with angiotensin II receptor blocker and her proteinuria diminished; however, 1 year after the delivery, she developed proteinuria again, along with microscopic hematuria and hypocomplementemia. A third renal biopsy was conducted at 31 years of age and she was diagnosed as having membranoproliferative glomerulonephritis (MPGN) type I on the basis of diffuse mesangial proliferation, endocapillary hypercellularity with double contour of the capillary wall, and lobular formation in glomeruli, as determined by light microscopy. Immunofluorescence staining demonstrated deposits of C3, C4, C1q, and IgM in the mesangial region and capillary wall. She underwent corticosteroid therapy followed by normalization of urinalysis and serum complement level. Although she had initially been diagnosed with ‘IgM nephropathy’, she was finally diagnosed with secondary MPGN and was successfully treated by corticosteroid therapy. |
doi_str_mv | 10.1007/s13730-012-0042-1 |
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She had a past history of two renal biopsies. When she was 12 years old, she developed proteinuria, microscopic hematuria, and hypocomplementemia. She was diagnosed as having ‘IgM nephropathy’ based on minor glomerular abnormalities as determined by light microscopy and IgM and C3 deposition in the mesangial region by immunofluorescence microscopy at the first biopsy. Despite corticosteroid treatment, her proteinuria did not improve and she discontinued regular outpatient checkups. When she was 29 years old and pregnant, she developed preeclampsia and, after delivery, a second renal biopsy was implemented. She was diagnosed as having progressed ‘IgM nephropathy’ with endotheliosis induced by preeclampsia. She was treated with angiotensin II receptor blocker and her proteinuria diminished; however, 1 year after the delivery, she developed proteinuria again, along with microscopic hematuria and hypocomplementemia. A third renal biopsy was conducted at 31 years of age and she was diagnosed as having membranoproliferative glomerulonephritis (MPGN) type I on the basis of diffuse mesangial proliferation, endocapillary hypercellularity with double contour of the capillary wall, and lobular formation in glomeruli, as determined by light microscopy. Immunofluorescence staining demonstrated deposits of C3, C4, C1q, and IgM in the mesangial region and capillary wall. She underwent corticosteroid therapy followed by normalization of urinalysis and serum complement level. Although she had initially been diagnosed with ‘IgM nephropathy’, she was finally diagnosed with secondary MPGN and was successfully treated by corticosteroid therapy.</description><identifier>ISSN: 2192-4449</identifier><identifier>EISSN: 2192-4449</identifier><identifier>DOI: 10.1007/s13730-012-0042-1</identifier><identifier>PMID: 28509225</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Case Report ; Medicine ; Medicine & Public Health ; Nephrology ; Urology</subject><ispartof>CEN case reports, 2013-05, Vol.2 (1), p.76-83</ispartof><rights>Japanese Society of Nephrology 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-7c6b32a4c9770f9c4af6c3331ce60a43c8dae83459a934062b8a3c3dae2f0b6c3</citedby><cites>FETCH-LOGICAL-c427t-7c6b32a4c9770f9c4af6c3331ce60a43c8dae83459a934062b8a3c3dae2f0b6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413730/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413730/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28509225$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaneko, Yoshikatsu</creatorcontrib><creatorcontrib>Yoshita, Kazuhiro</creatorcontrib><creatorcontrib>Kabasawa, Hideyuki</creatorcontrib><creatorcontrib>Imai, Naofumi</creatorcontrib><creatorcontrib>Ito, Yumi</creatorcontrib><creatorcontrib>Ueno, Mitsuhiro</creatorcontrib><creatorcontrib>Nishi, Shinichi</creatorcontrib><creatorcontrib>Narita, Ichiei</creatorcontrib><title>A case of membranoproliferative glomerulonephritis developed over twenty years with three different findings of renal pathology</title><title>CEN case reports</title><addtitle>CEN Case Rep</addtitle><addtitle>CEN Case Rep</addtitle><description>A 31-year-old woman with proteinuria, hypocomplementemia, rheumatoid factor, and high serum polyclonal IgM concentration was admitted to our hospital for renal biopsy. She had a past history of two renal biopsies. When she was 12 years old, she developed proteinuria, microscopic hematuria, and hypocomplementemia. She was diagnosed as having ‘IgM nephropathy’ based on minor glomerular abnormalities as determined by light microscopy and IgM and C3 deposition in the mesangial region by immunofluorescence microscopy at the first biopsy. Despite corticosteroid treatment, her proteinuria did not improve and she discontinued regular outpatient checkups. When she was 29 years old and pregnant, she developed preeclampsia and, after delivery, a second renal biopsy was implemented. She was diagnosed as having progressed ‘IgM nephropathy’ with endotheliosis induced by preeclampsia. She was treated with angiotensin II receptor blocker and her proteinuria diminished; however, 1 year after the delivery, she developed proteinuria again, along with microscopic hematuria and hypocomplementemia. A third renal biopsy was conducted at 31 years of age and she was diagnosed as having membranoproliferative glomerulonephritis (MPGN) type I on the basis of diffuse mesangial proliferation, endocapillary hypercellularity with double contour of the capillary wall, and lobular formation in glomeruli, as determined by light microscopy. Immunofluorescence staining demonstrated deposits of C3, C4, C1q, and IgM in the mesangial region and capillary wall. She underwent corticosteroid therapy followed by normalization of urinalysis and serum complement level. Although she had initially been diagnosed with ‘IgM nephropathy’, she was finally diagnosed with secondary MPGN and was successfully treated by corticosteroid therapy.</description><subject>Case Report</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephrology</subject><subject>Urology</subject><issn>2192-4449</issn><issn>2192-4449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9UU1P3DAQtVArQMAP6KXysZcUf-0mvlRCiLZISL2Us-U448TIiVPbWbQ3fgq_pb-sXhYQXHoaa96b98bzEPpEyVdKSH2eKK85qQhlFSGCVfQAHTMqWSWEkB_evI_QWUp3hBDKBVkReYiOWFMqY6tj9HCBjU6Ag8UjjG3UU5hj8M5C1NltAPc-jBAXHyaYh-iyS7iDDfgwQ4fDBiLO9zDl7d_HLeiY8L3LA85DBMCds0WmgNi6qXNTn3Y2paE9nnUegg_99hR9tNonOHuuJ-j2-9Xvy5_Vza8f15cXN5URrM5VbdYtZ1oYWdfESiO0XRvOOTWwJlpw03QaGi5WUsvyzTVrG80NL01mSVuoJ-jbXnde2hE6U9aK2qs5ulHHrQraqffI5AbVh41aiadDF4EvzwIx_FkgZTW6ZMB7PUFYkqKNlMWYCFmodE81MaQUwb7aUKJ24al9eKqEp3bhKVpmPr_d73XiJapCYHtCKtDUQ1R3YYnlluk_qv8AMAyqRg</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Kaneko, Yoshikatsu</creator><creator>Yoshita, Kazuhiro</creator><creator>Kabasawa, Hideyuki</creator><creator>Imai, Naofumi</creator><creator>Ito, Yumi</creator><creator>Ueno, Mitsuhiro</creator><creator>Nishi, Shinichi</creator><creator>Narita, Ichiei</creator><general>Springer Japan</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130501</creationdate><title>A case of membranoproliferative glomerulonephritis developed over twenty years with three different findings of renal pathology</title><author>Kaneko, Yoshikatsu ; Yoshita, Kazuhiro ; Kabasawa, Hideyuki ; Imai, Naofumi ; Ito, Yumi ; Ueno, Mitsuhiro ; Nishi, Shinichi ; Narita, Ichiei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-7c6b32a4c9770f9c4af6c3331ce60a43c8dae83459a934062b8a3c3dae2f0b6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Case Report</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephrology</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaneko, Yoshikatsu</creatorcontrib><creatorcontrib>Yoshita, Kazuhiro</creatorcontrib><creatorcontrib>Kabasawa, Hideyuki</creatorcontrib><creatorcontrib>Imai, Naofumi</creatorcontrib><creatorcontrib>Ito, Yumi</creatorcontrib><creatorcontrib>Ueno, Mitsuhiro</creatorcontrib><creatorcontrib>Nishi, Shinichi</creatorcontrib><creatorcontrib>Narita, Ichiei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>CEN case reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaneko, Yoshikatsu</au><au>Yoshita, Kazuhiro</au><au>Kabasawa, Hideyuki</au><au>Imai, Naofumi</au><au>Ito, Yumi</au><au>Ueno, Mitsuhiro</au><au>Nishi, Shinichi</au><au>Narita, Ichiei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A case of membranoproliferative glomerulonephritis developed over twenty years with three different findings of renal pathology</atitle><jtitle>CEN case reports</jtitle><stitle>CEN Case Rep</stitle><addtitle>CEN Case Rep</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>2</volume><issue>1</issue><spage>76</spage><epage>83</epage><pages>76-83</pages><issn>2192-4449</issn><eissn>2192-4449</eissn><abstract>A 31-year-old woman with proteinuria, hypocomplementemia, rheumatoid factor, and high serum polyclonal IgM concentration was admitted to our hospital for renal biopsy. She had a past history of two renal biopsies. When she was 12 years old, she developed proteinuria, microscopic hematuria, and hypocomplementemia. She was diagnosed as having ‘IgM nephropathy’ based on minor glomerular abnormalities as determined by light microscopy and IgM and C3 deposition in the mesangial region by immunofluorescence microscopy at the first biopsy. Despite corticosteroid treatment, her proteinuria did not improve and she discontinued regular outpatient checkups. When she was 29 years old and pregnant, she developed preeclampsia and, after delivery, a second renal biopsy was implemented. She was diagnosed as having progressed ‘IgM nephropathy’ with endotheliosis induced by preeclampsia. She was treated with angiotensin II receptor blocker and her proteinuria diminished; however, 1 year after the delivery, she developed proteinuria again, along with microscopic hematuria and hypocomplementemia. A third renal biopsy was conducted at 31 years of age and she was diagnosed as having membranoproliferative glomerulonephritis (MPGN) type I on the basis of diffuse mesangial proliferation, endocapillary hypercellularity with double contour of the capillary wall, and lobular formation in glomeruli, as determined by light microscopy. Immunofluorescence staining demonstrated deposits of C3, C4, C1q, and IgM in the mesangial region and capillary wall. She underwent corticosteroid therapy followed by normalization of urinalysis and serum complement level. Although she had initially been diagnosed with ‘IgM nephropathy’, she was finally diagnosed with secondary MPGN and was successfully treated by corticosteroid therapy.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>28509225</pmid><doi>10.1007/s13730-012-0042-1</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Case Report Medicine Medicine & Public Health Nephrology Urology |
title | A case of membranoproliferative glomerulonephritis developed over twenty years with three different findings of renal pathology |
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