Trigeminal brainstem modulation of persistent orbicularis oculi muscle activity in a rat model of dry eye

Highlights • Muscimol injection into ViVc transition caused a greater inhibition of evoked OOemg activity in DE than sham rats. • Muscimol injection into VcC1 caused a smaller decrease in evoked OOemg activity in DE and sham rats. • BMI injection into ViVc transition or VcC1 enhanced evoked OOemg ac...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2017-05, Vol.349, p.208-219
Hauptverfasser:	Rahman, Mostafeezur, Shiozaki, Kazunari, Okamoto, Keiichiro, Thompson, Randall, Bereiter, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blinking - drug effects Blinking - physiology Brain Stem - drug effects Brain Stem - metabolism Brain Stem - physiopathology corneal reflex Disease Models, Animal dry eye Dry Eye Syndromes - drug therapy Dry Eye Syndromes - physiopathology electromyography GABA receptor Male N-Methylaspartate - metabolism Neurology Neurons - metabolism NMDA receptor orbicularis oculi Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - metabolism Saline Solution, Hypertonic - pharmacology Synaptic Transmission - drug effects Trigeminal Nerve - drug effects Trigeminal Nerve - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Muscimol injection into ViVc transition caused a greater inhibition of evoked OOemg activity in DE than sham rats. • Muscimol injection into VcC1 caused a smaller decrease in evoked OOemg activity in DE and sham rats. • BMI injection into ViVc transition or VcC1 enhanced evoked OOemg activity in DE rats. • AP5 injection into ViVc transition or VcC1 region greatly reduced evoked OOemg activity in DE and sham rats. • GABAαβ3 receptor density was reduced at ViVc, while pNR1 was increased at ViVc and VcC1 in DE versus sham rats.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2017.03.003