Antiretroviral Activity Of a Novel Pyrimidyl-Di(Diazaspiroalkane) Derivative

Antiretroviral Activity Of a Novel Pyrimidyl-Di(Diazaspiroalkane) Derivative

A novel compound, 3,3'-(5-nitropyrimidine-4,6-diyl)bis-3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane tetrachloride dihydrochloride, was synthesized. The compound was found to inhibit the replication of various viral families by blocking specific heparan sulfate receptors on the host cell�...

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Veröffentlicht in:Actanaturae 2017-01, Vol.9 (1), p.105-107
Hauptverfasser: Novoselova, E A, Riabova, O B, Leneva, I A, Nesterenko, V G, Bolgarin, R N, Makarov, V A
Format: Artikel
Sprache:eng
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Zusammenfassung:A novel compound, 3,3'-(5-nitropyrimidine-4,6-diyl)bis-3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane tetrachloride dihydrochloride, was synthesized. The compound was found to inhibit the replication of various viral families by blocking specific heparan sulfate receptors on the host cell's surface. In experiments, the compound was found to be highly effective against several strains of HIV retroviruses.
ISSN:2075-8251
DOI:10.32607/20758251-2017-9-1-105-107