Genetic determinants of adiponectin regulation revealed by pregnancy

Genetic determinants of adiponectin regulation revealed by pregnancy

Objective This study investigated genetic determinants of adiponectin during pregnancy to reveal novel biology of adipocyte regulation. Methods A genome‐wide association study was conducted in 1,322 pregnant women from the Hyperglycemia and Adverse Pregnancy Outcome Study with adiponectin measured a...

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Veröffentlicht in:Obesity (Silver Spring, Md.) Md.), 2017-05, Vol.25 (5), p.935-944
Hauptverfasser: Hivert, Marie‐France, Scholtens, Denise M., Allard, Catherine, Nodzenski, Michael, Bouchard, Luigi, Brisson, Diane, Lowe, Lynn P., McDowell, Ian, Reddy, Tim, Dastani, Zari, Richards, J. Brent, Hayes, M. Geoffrey, Lowe, William L.
Format: Artikel
Sprache:eng
Schlagworte:
Adipocytes
Adiponectin - blood
Adiponectin - genetics
Adult
Biology
Body mass index
Cohort Studies
Consent
Consortia
Diabetes
Fasting
Female
Gene expression
Genealogy
Genetics
Genome-Wide Association Study
Genomes
Humans
Hyperglycemia
Insulin resistance
Metabolism
Obesity
Pregnancy
Review boards
Standard deviation
Studies
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Zusammenfassung:Objective This study investigated genetic determinants of adiponectin during pregnancy to reveal novel biology of adipocyte regulation. Methods A genome‐wide association study was conducted in 1,322 pregnant women from the Hyperglycemia and Adverse Pregnancy Outcome Study with adiponectin measured at ∼28 weeks of gestation. Variants reaching P 
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.21805