Luteolin, a novel p90 ribosomal S6 kinase inhibitor, suppresses proliferation and migration in leukemia cells

Luteolin, a novel p90 ribosomal S6 kinase inhibitor, suppresses proliferation and migration in leukemia cells

Ribosomal S6 kinases (RSKs) are directly regulated by extracellular signal-regulated kinase (ERK) signaling and are implicated in cell growth, survival, motility and senescence. The present study observed that RSK1 was overexpressed in primary untreated leukemia patient bone marrow samples compared...

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Veröffentlicht in:Oncology letters 2017-03, Vol.13 (3), p.1370-1378
Hauptverfasser: Deng, Lan, Jiang, Ling, Lin, Xianghua, Tseng, Kuo-Fu, Lu, Zhigang, Wang, Xiuju
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Bioflavonoids
Bone marrow
Cancer therapies
Care and treatment
Cell growth
Chemotherapy
Development and progression
Flavones
Flavonoids
Gene expression
Genetic aspects
Health aspects
Kinases
Leukemia
Melanoma
Oncology
Phosphorylation
Phosphotransferases
Proteins
Thermal cycling
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Zusammenfassung:Ribosomal S6 kinases (RSKs) are directly regulated by extracellular signal-regulated kinase (ERK) signaling and are implicated in cell growth, survival, motility and senescence. The present study observed that RSK1 was overexpressed in primary untreated leukemia patient bone marrow samples compared with the expression at the complete remission stage, using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). In addition, a high RSK1 expression (relative expression ≥10) was associated with a significantly shorter overall survival (P=0.038) compared with that in patients with low RSK1 expression (relative expression
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2017.5597