Neuroimmune mechanisms of behavioral alterations in a syngeneic murine model of human papilloma virus-related head and neck cancer

Highlights • Tumor inflammation is associated with increased liver and brain inflammation. • The tumor-induced a behavioral phenotype resembling mild fatigue. • Lipopolysaccharide exacerbates tumor-induced behavioral and inflammatory profile. • Minocycline treatment attenuates tumor-induced burrowin...

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Veröffentlicht in:	Psychoneuroendocrinology 2017-05, Vol.79, p.59-66
Hauptverfasser:	Vichaya, Elisabeth G, Vermeer, Daniel W, Christian, Diana L, Molkentine, Jessica M, Mason, Kathy A, Lee, John H, Dantzer, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Cytokines Cytokines - metabolism Disease Models, Animal Endocrinology & Metabolism Fatigue Head and Neck Neoplasms - immunology Head and Neck Neoplasms - pathology Head and Neck Neoplasms - virology Human papilloma virus Illness Behavior Inflammation Male Mice Mice, Inbred C57BL Motor Activity Neuroimmunomodulation Papillomaviridae Psychiatry Sickness behavior
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Zusammenfassung:	Highlights • Tumor inflammation is associated with increased liver and brain inflammation. • The tumor-induced a behavioral phenotype resembling mild fatigue. • Lipopolysaccharide exacerbates tumor-induced behavioral and inflammatory profile. • Minocycline treatment attenuates tumor-induced burrowing deficits and inflammation. • However, the inflammation profile differs from classical inflammatory models.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2017.02.006