Influence of sleep deprivation and circadian misalignment on cortisol, inflammatory markers, and cytokine balance

Highlights • Sleep deprivation and circadian misalignment have opposite effects on cortisol. • Acute total sleep deprivation increases cortisol levels. • Chronic circadian misalignment reduces 24-hour cortisol levels. • Chronic circadian misalignment increases TNF-α, CRP and IL-10 levels.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2015-07, Vol.47, p.24-34
Hauptverfasser:	Wright, Kenneth P, Drake, Amanda L, Frey, Danielle J, Fleshner, Monika, Desouza, Christopher A, Gronfier, Claude, Czeisler, Charles A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy and Immunology Biomarkers - blood C-reactive protein C-Reactive Protein - metabolism Circadian clock Circadian Rhythm - physiology Cortisol Cytokines Female Humans Hydrocortisone - blood Inflammation Interleukin-10 Interleukin-10 - blood Life Sciences Male Melatonin - blood Psychiatry Sleep Deprivation - blood Sleep loss Stress, Physiological - physiology Tumor necrosis factor alpha Tumor Necrosis Factor-alpha - blood Young Adult
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Beschreibung
Zusammenfassung:	Highlights • Sleep deprivation and circadian misalignment have opposite effects on cortisol. • Acute total sleep deprivation increases cortisol levels. • Chronic circadian misalignment reduces 24-hour cortisol levels. • Chronic circadian misalignment increases TNF-α, CRP and IL-10 levels.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2015.01.004