Excess BMI in Childhood: A Modifiable Risk Factor for Type 1 Diabetes Development?

We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth. We studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age- and...

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Veröffentlicht in:	Diabetes care 2017-05, Vol.40 (5), p.698-701
Hauptverfasser:	Ferrara, Christine Therese, Geyer, Susan Michelle, Liu, Yuk-Fun, Evans-Molina, Carmella, Libman, Ingrid M, Besser, Rachel, Becker, Dorothy J, Rodriguez, Henry, Moran, Antoinette, Gitelman, Stephen E, Redondo, Maria J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age Age Factors Body mass Body Mass Index Child Child, Preschool Childhood Children Children & youth Childrens health Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - etiology Female Females Health risks Humans Male Males Multivariate Analysis Novel Communications in Diabetes Pediatric Obesity - complications Pediatrics Research design Risk assessment Risk Factors Sex Sex Factors Thresholds
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Zusammenfassung:	We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth. We studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age- and sex-adjusted percentile generated a cumulative excess BMI (ceBMI) index. Recursive partitioning and multivariate analyses yielded sex- and age-specific ceBMI thresholds for greatest type 1 diabetes risk. Higher ceBMI conferred significantly greater risk of progressing to type 1 diabetes. The increased diabetes risk occurred at lower ceBMI values in children
ISSN:	0149-5992 1935-5548
DOI:	10.2337/dc16-2331