Optogenetic approaches for dissecting neuromodulation and GPCR signaling in neural circuits

Highlights • Optogenetic tools provide precise spatial and temporal control of GPCR signaling. • Light-sensitive proteins can be engineered for GPCR-specific applications. • Advances in imaging technology are paving new pathways in vitro and in vivo GPCR research.

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Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in pharmacology 2017-02, Vol.32, p.56-70
Hauptverfasser:	Spangler, Skylar M, Bruchas, Michael R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biosensing Techniques - methods Genetic Vectors - genetics Humans Integrases - genetics Internal Medicine Medical Education Neural Pathways - physiology Opsins - metabolism Optogenetics - methods Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Signal Transduction - genetics Signal Transduction - physiology
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Beschreibung
Zusammenfassung:	Highlights • Optogenetic tools provide precise spatial and temporal control of GPCR signaling. • Light-sensitive proteins can be engineered for GPCR-specific applications. • Advances in imaging technology are paving new pathways in vitro and in vivo GPCR research.
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2016.11.001