Rubella persistence in epidermal keratinocytes and granuloma M2 macrophages in patients with primary immunodeficiencies

[...]current data have clearly shown an association between defects in T-cell immunity, granulomas, and RV. A role for vaccine virus in Fuchs' uveitis is also suspected.7,8 Granulomas have been reported only once in CRS.9 We hypothesize that the immune deficiency allows persistence of the atten...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2016-11, Vol.138 (5), p.1436-1439.e11
Hauptverfasser:	Perelygina, Ludmila, PhD, Plotkin, Stanley, MD, Russo, Pierre, MD, Hautala, Timo, MD, PhD, Bonilla, Francisco, MD, PhD, Ochs, Hans D., MD, Joshi, Avni, MD, MSc, Routes, John, MD, Patel, Kiran, MD, MS, Wehr, Claudia, MD, Icenogle, Joseph, PhD, Sullivan, Kathleen E., MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy and Immunology Antigens Child Child, Preschool Epidermis - immunology Epidermis - pathology Epidermis - virology Granuloma - immunology Granuloma - pathology Granuloma - virology Humans Immunologic Deficiency Syndromes - pathology Immunologic Deficiency Syndromes - virology Infant Keratin Keratinocytes - immunology Keratinocytes - pathology Keratinocytes - virology Macrophages - immunology Macrophages - pathology Macrophages - virology Middle Aged Mutation Patients Rubella Rubella - immunology Rubella - pathology Rubella virus - immunology Skin Vaccines Young Adult
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Zusammenfassung:	[...]current data have clearly shown an association between defects in T-cell immunity, granulomas, and RV. A role for vaccine virus in Fuchs' uveitis is also suspected.7,8 Granulomas have been reported only once in CRS.9 We hypothesize that the immune deficiency allows persistence of the attenuated virus, polarization of macrophages to M2 occurs, compromising viral clearance, mutations accrue, and complete viral escape occurs upon acquisition of CD8 epitope mutations.\nFin/22.15/PID Epitope Epitope sequence in vaccine virus Substitutions in patients' virus Neutralizing B-cell epitopes E1214-233[low *] QQSRWGLGSPNCHGPDWASP None E1245-251 LVGATPE None E1260-266 ADDPLLR None E1274-285 VWVTPVIGSQAR I280[arrow right]T CD8+ T-cell epitopes C9-22 MEDLQKALETQSRA T18[arrow right]A C11-29 DLQKALETQSRALRAELAA T18[arrow right]A C264-272 RIETRSARH T267[arrow right]I Table E4 Changes in the antigenic structure of RV antigens of RVs/Oulu.FIN/22.15/PID relative to RA27/3 vaccine Antigen Type Vendor Catalog no.
ISSN:	0091-6749 1097-6825
DOI:	10.1016/j.jaci.2016.06.030