3D structure of individual mammalian genomes studied by single cell Hi-C

3D structure of individual mammalian genomes studied by single cell Hi-C

The folding of genomic DNA from the beads-on-a-string like structure of nucleosomes into higher order assemblies is critically linked to nuclear processes. We have calculated the first 3D structures of entire mammalian genomes using data from a new chromosome conformation capture procedure that allo...

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Veröffentlicht in:Nature (London) 2017-03, Vol.544 (7648), p.59-64
Hauptverfasser: Stevens, Tim J., Lando, David, Basu, Srinjan, Atkinson, Liam P., Cao, Yang, Lee, Steven F., Leeb, Martin, Wohlfahrt, Kai J., Boucher, Wayne, O’Shaughnessy-Kirwan, Aoife, Cramard, Julie, Faure, Andre J., Ralser, Meryem, Blanco, Enrique, Morey, Lluis, Sansó, Miriam, Palayret, Matthieu G. S., Lehner, Ben, Di Croce, Luciano, Wutz, Anton, Hendrich, Brian, Klenerman, Dave, Laue, Ernest D.
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Sprache:eng
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Zusammenfassung:The folding of genomic DNA from the beads-on-a-string like structure of nucleosomes into higher order assemblies is critically linked to nuclear processes. We have calculated the first 3D structures of entire mammalian genomes using data from a new chromosome conformation capture procedure that allows us to first image and then process single cells. This has allowed us to study genome folding down to a scale of
ISSN:0028-0836
1476-4687
DOI:10.1038/nature21429