Dynein at kinetochores: Making the connection

Dynein at kinetochores: Making the connection

Dynein removes the checkpoint proteins from kinetochores once chromosomes are bioriented. In this issue, Gama et al. (2017. https://doi.org/10.1083/jcb.201610108) and Mosalaganti et al. (2017. https://doi.org/10.1083/jcb.201611060) reveal the molecular basis for how dynein and its adaptor protein Sp...

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Veröffentlicht in:The Journal of cell biology 2017-04, Vol.216 (4), p.855-857
Hauptverfasser: McHugh, Toni, Welburn, Julie P I
Format: Artikel
Sprache:eng
Schlagworte:
Cell Cycle Proteins - metabolism
Cells
Cellular biology
Chromosomes
Chromosomes - metabolism
Dynein
Dyneins - metabolism
Humans
Intracellular Signaling Peptides and Proteins - metabolism
Kinetochores
Kinetochores - metabolism
Microtubule-Associated Proteins - metabolism
Microtubules - metabolism
Mitosis
Molecules
Nuclear Proteins - metabolism
Proteins
Spindle Apparatus - metabolism
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Beschreibung
Zusammenfassung:Dynein removes the checkpoint proteins from kinetochores once chromosomes are bioriented. In this issue, Gama et al. (2017. https://doi.org/10.1083/jcb.201610108) and Mosalaganti et al. (2017. https://doi.org/10.1083/jcb.201611060) reveal the molecular basis for how dynein and its adaptor protein Spindly are recruited to the ROD-Zw10-Zwilch complex in the fibrous corona of unattached kinetochores.
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.201703054