The placental interleukin-6 signaling controls fetal brain development and behavior

The placental interleukin-6 signaling controls fetal brain development and behavior

Highlights • IL-6 downstream signaling is activated in specific regions of fetal hindbrain after MIA. • Placental IL-6Rα knockout prevents MIA induced inflammatory responses in placental-fetal axis. • MIA-induced behavioral abnormalities are prevented in placental IL-6Rα knockout mice. • MIA-induced...

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Veröffentlicht in:Brain, behavior, and immunity behavior, and immunity, 2017-05, Vol.62, p.11-23
Hauptverfasser: Wu, Wei-Li, Hsiao, Elaine Y, Yan, Zihao, Mazmanian, Sarkis K, Patterson, Paul H
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
Autism spectrum disorder (ASD)
Behavior, Animal - physiology
Brain - embryology
Brain - metabolism
Female
Fetal Development - physiology
Hindbrain development
Interleukin-6 (IL-6)
Interleukin-6 - metabolism
Maternal immune activation (MIA)
Maternal-placental-fetal axis
Mice
Mice, Knockout
Placenta
Placenta - metabolism
Pregnancy
Psychiatry
Purkinje cells
Receptors, Interleukin-6 - genetics
Receptors, Interleukin-6 - metabolism
Signal Transduction - physiology
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Zusammenfassung:Highlights • IL-6 downstream signaling is activated in specific regions of fetal hindbrain after MIA. • Placental IL-6Rα knockout prevents MIA induced inflammatory responses in placental-fetal axis. • MIA-induced behavioral abnormalities are prevented in placental IL-6Rα knockout mice. • MIA-induced cerebellar neuropathologies are prevented in placental IL-6Rα knockout mice.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.11.007