Preeclampsia and ESRD: The Role of Shared Risk Factors

Background Several registry-based studies, using diagnostic codes, have suggested that preeclampsia is a risk factor for end-stage renal disease (ESRD). However, because the 2 diseases share risk factors, the true nature of their association remains uncertain. Our goals were to conduct a population-...

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Veröffentlicht in:American journal of kidney diseases 2017-04, Vol.69 (4), p.498-505
Hauptverfasser: Kattah, Andrea G., MD, Scantlebury, Dawn C., MBBS, Agarwal, Sanket, MBBS, Mielke, Michelle M., PhD, Rocca, Walter A., MD, MPH, Weaver, Amy L., MS, Vaughan, Lisa E., MS, Miller, Virginia M., PhD, Weissgerber, Tracey L., PhD, White, Wendy, MD, Garovic, Vesna D., MD
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Sprache:eng
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Zusammenfassung:Background Several registry-based studies, using diagnostic codes, have suggested that preeclampsia is a risk factor for end-stage renal disease (ESRD). However, because the 2 diseases share risk factors, the true nature of their association remains uncertain. Our goals were to conduct a population-based study to determine the magnitude of the association between preeclampsia and ESRD and evaluate the role of shared risk factors. Study Design Population-based nested case-control study. Setting & Participants The US Renal Data System was used to identify women with ESRD from a cohort of 34,581 women who gave birth in 1976 to 2010 in Olmsted County, MN. 44 cases of ESRD were identified and each one was matched to 2 controls based on year of birth (±1 year), age at first pregnancy (±2 years), and parity (±1 or ≥4). Predictor Preeclamptic pregnancy, confirmed by medical record review. Outcome ESRD. Measurements Prepregnancy serum creatinine and urine protein measurements were recorded. Comorbid conditions existing prior to pregnancy were abstracted from medical records and included kidney disease, obesity, diabetes, and hypertension. Results There was evidence of kidney disease prior to the first pregnancy in 9 of 44 (21%) cases and 1 of 88 (
ISSN:0272-6386
1523-6838
DOI:10.1053/j.ajkd.2016.07.034