Global Molecular Epidemiology of IMP-Producing Enterobacteriaceae

International data on the molecular epidemiology of with IMP carbapenemases are lacking. We performed short-read (Illumina) whole-genome sequencing on a global collection of 38 IMP-producing clinical (2008 to 2014). IMP-producing (7 varieties within 11 class 1 integrons) were mainly present in the South Pacific and Asia. Specific -containing integrons (In809 with , In722 with , and In687 with ) were circulating among different bacteria in countries such as Australia, Japan, and Thailand. In1312 with was present in from Japan and from Brazil. ( = 22) was the most common species; clonal complex 14 (CC14) from Philippines and Japan was the most common clone and contained In1310 with and In1321 with The complex ( = 9) consisted of and cluster III. CC78 (from Taiwan) containing In73 with was the most common clone among the complex. This study highlights the importance of surveillance programs using the latest molecular techniques for providing insight into the characteristics and global distribution of with genes.