Clinical significance of Wip1 overexpression and its association with the p38MAPK/p53/p16 pathway in NSCLC

Wip1 is deregulated in numerous human malignancies. However, its roles in non-small cell lung cancer (NSCLC) remain unclear. In the current study, the expression of Wip1 was investigated in NSCLC and its clinical significance was detected. Immunohistochemical staining was used to measure the express...

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Veröffentlicht in:	Molecular medicine reports 2017-02, Vol.15 (2), p.719-723
Hauptverfasser:	Yang, Shize, Dong, Siyuan, Qu, Xiaohan, Zhong, Xinwen, Zhang, Qigang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Apoptosis Breast cancer Cancer therapies Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - physiopathology Cell cycle Cell Line, Tumor Chemotherapy Clinical significance Cyclin-Dependent Kinase Inhibitor p16 - metabolism DNA damage Female Gene Expression Genetic aspects Humans Immunoglobulins Immunohistochemistry Kinases Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - physiopathology Lymphatic system Male MAP kinase Metastasis Middle Aged Neoplasm Staging Non-small cell lung cancer Non-small cell lung carcinoma NSCLC p16 p16 Protein p38 Mitogen-Activated Protein Kinases - metabolism p38MAPK p53 p53 Protein Phosphatase Protein kinase Protein Phosphatase 2C - genetics Protein Phosphatase 2C - metabolism Proteins Radiation therapy Signal Transduction Software Studies Tumor Suppressor Protein p53 - metabolism Western blotting Wip1
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Zusammenfassung:	Wip1 is deregulated in numerous human malignancies. However, its roles in non-small cell lung cancer (NSCLC) remain unclear. In the current study, the expression of Wip1 was investigated in NSCLC and its clinical significance was detected. Immunohistochemical staining was used to measure the expression of (wild-type p53 induced phosphatase 1) Wip1, p38 mitogen-activated protein kinase (MAPK), p53, p16 protein in a group of 60 NSCLC and 20 normal lung tissues. In addition, western blotting was performed to detect the Wip1 protein in fresh tissues. The correlations between clinical characteristics and Wip1 expression were analyzed using SPSS, version 16.0 software. The expression of Wip1 was positive in 63.3% (38/60) of NSCLC tissues, and in none of the normal lung tissues (0/20; P
ISSN:	1791-2997 1791-3004
DOI:	10.3892/mmr.2016.6032