Circulating tumor cell status monitors the treatment responses in breast cancer patients: a meta-analysis

Whether circulating tumor cells (CTCs) can be used as an indicator of treatment response in breast cancer (BC) needs to be clarified. We addressed this issue by a meta-analysis. PubMed, EMBase and Cochrane library databases were searched in June 2016. Effect measures were estimated as pooled risk ra...

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Veröffentlicht in:	Scientific reports 2017-03, Vol.7 (1), p.43464-43464, Article 43464
Hauptverfasser:	Yan, Wen-Ting, Cui, Xiang, Chen, Qing, Li, Ya-Fei, Cui, You-Hong, Wang, Yan, Jiang, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1347 692/4028/67/1347 Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - mortality Disease Progression ErbB-2 protein Female Gene Expression Heterogeneity Humanities and Social Sciences Humans Meta-analysis Metastases Monitoring, Physiologic multidisciplinary Neoadjuvant Therapy - methods Neoplastic Cells, Circulating - drug effects Neoplastic Cells, Circulating - pathology Odds Ratio Prognosis Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Risk Factors Science Surgery Survival Survival Analysis Tumor cells
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Zusammenfassung:	Whether circulating tumor cells (CTCs) can be used as an indicator of treatment response in breast cancer (BC) needs to be clarified. We addressed this issue by a meta-analysis. PubMed, EMBase and Cochrane library databases were searched in June 2016. Effect measures were estimated as pooled risk ratio (RR), odds ratio (OR) or mean difference by fixed- or random-effect models, according to heterogeneity of included studies. In total, 50 studies with 6712 patients were recruited. Overall analysis showed that there was a significant reduction of CTC-positive rate (RR = 0.68, 95% CI: 0.61–0.76, P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/srep43464