Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals
Risk factors and cognitive sequelae of brain arteriolosclerosis pathology are not fully understood. To address this, we used multimodal data from the National Alzheimer's Coordinating Center and Alzheimer's Disease Neuroimaging Initiative data sets. Previous studies showed evidence of dist...
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| Veröffentlicht in: | Journal of cerebral blood flow and metabolism 2017-01, Vol.37 (1), p.201-216 |
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| creator | Ighodaro, Eseosa T Abner, Erin L Fardo, David W Lin, Ai-Ling Katsumata, Yuriko Schmitt, Frederick A Kryscio, Richard J Jicha, Gregory A Neltner, Janna H Monsell, Sarah E Kukull, Walter A Moser, Debra K Appiah, Frank Bachstetter, Adam D Van Eldik, Linda J Nelson, Peter T |
| description | Risk factors and cognitive sequelae of brain arteriolosclerosis pathology are not fully understood. To address this, we used multimodal data from the National Alzheimer's Coordinating Center and Alzheimer's Disease Neuroimaging Initiative data sets. Previous studies showed evidence of distinct neurodegenerative disease outcomes and clinical-pathological correlations in the “oldest-old” compared to younger cohorts. Therefore, using the National Alzheimer's Coordinating Center data set, we analyzed clinical and neuropathological data from two groups according to ages at death: |
| doi_str_mv | 10.1177/0271678X15621574 |
| format | Article |
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To address this, we used multimodal data from the National Alzheimer's Coordinating Center and Alzheimer's Disease Neuroimaging Initiative data sets. Previous studies showed evidence of distinct neurodegenerative disease outcomes and clinical-pathological correlations in the “oldest-old” compared to younger cohorts. Therefore, using the National Alzheimer's Coordinating Center data set, we analyzed clinical and neuropathological data from two groups according to ages at death: < 80 years (n = 1008) and ≥80 years (n = 1382). In both age groups, severe brain arteriolosclerosis was associated with worse performances on global cognition tests. Hypertension (but not diabetes) was a brain arteriolosclerosis risk factor in the younger group. In the ≥ 80 years age at death group, an ABCC9 gene variant (rs704180), previously associated with aging-related hippocampal sclerosis, was also associated with brain arteriolosclerosis. A post-hoc arterial spin labeling neuroimaging experiment indicated that ABCC9 genotype is associated with cerebral blood flow impairment; in a convenience sample from Alzheimer's Disease Neuroimaging Initiative (n = 15, homozygous individuals), non-risk genotype carriers showed higher global cerebral blood flow compared to risk genotype carriers. We conclude that brain arteriolosclerosis is associated with altered cognitive status and a novel vascular genetic risk factor.</description><identifier>ISSN: 0271-678X</identifier><identifier>EISSN: 1559-7016</identifier><identifier>DOI: 10.1177/0271678X15621574</identifier><identifier>PMID: 26738751</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aged ; Aged, 80 and over ; Aging - psychology ; Arteriolosclerosis - etiology ; Arteriolosclerosis - genetics ; Arteriolosclerosis - psychology ; Brain - pathology ; Brain - physiopathology ; Cerebrovascular Circulation - genetics ; Cognition ; Databases, Factual ; Genetic Variation ; Humans ; Hypertension - complications ; Original ; Risk Factors ; Sulfonylurea Receptors - genetics</subject><ispartof>Journal of cerebral blood flow and metabolism, 2017-01, Vol.37 (1), p.201-216</ispartof><rights>The Author(s) 2016</rights><rights>The Author(s) 2016.</rights><rights>The Author(s) 2016 2016 International Society for Cerebral Blood Flow and Metabolism</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-f640586b4db90f27db354a3f6aa958f12e4a5692515d79e9952ce853897aae8a3</citedby><cites>FETCH-LOGICAL-c514t-f640586b4db90f27db354a3f6aa958f12e4a5692515d79e9952ce853897aae8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363738/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363738/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,21819,27924,27925,43621,43622,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26738751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ighodaro, Eseosa T</creatorcontrib><creatorcontrib>Abner, Erin L</creatorcontrib><creatorcontrib>Fardo, David W</creatorcontrib><creatorcontrib>Lin, Ai-Ling</creatorcontrib><creatorcontrib>Katsumata, Yuriko</creatorcontrib><creatorcontrib>Schmitt, Frederick A</creatorcontrib><creatorcontrib>Kryscio, Richard J</creatorcontrib><creatorcontrib>Jicha, Gregory A</creatorcontrib><creatorcontrib>Neltner, Janna H</creatorcontrib><creatorcontrib>Monsell, Sarah E</creatorcontrib><creatorcontrib>Kukull, Walter A</creatorcontrib><creatorcontrib>Moser, Debra K</creatorcontrib><creatorcontrib>Appiah, Frank</creatorcontrib><creatorcontrib>Bachstetter, Adam D</creatorcontrib><creatorcontrib>Van Eldik, Linda J</creatorcontrib><creatorcontrib>Nelson, Peter T</creatorcontrib><creatorcontrib>Alzheimer's Disease Neuroimaging Initiative (ADNI)</creatorcontrib><creatorcontrib>the Alzheimer's Disease Neuroimaging Initiative (ADNI)</creatorcontrib><title>Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals</title><title>Journal of cerebral blood flow and metabolism</title><addtitle>J Cereb Blood Flow Metab</addtitle><description>Risk factors and cognitive sequelae of brain arteriolosclerosis pathology are not fully understood. To address this, we used multimodal data from the National Alzheimer's Coordinating Center and Alzheimer's Disease Neuroimaging Initiative data sets. Previous studies showed evidence of distinct neurodegenerative disease outcomes and clinical-pathological correlations in the “oldest-old” compared to younger cohorts. Therefore, using the National Alzheimer's Coordinating Center data set, we analyzed clinical and neuropathological data from two groups according to ages at death: < 80 years (n = 1008) and ≥80 years (n = 1382). In both age groups, severe brain arteriolosclerosis was associated with worse performances on global cognition tests. Hypertension (but not diabetes) was a brain arteriolosclerosis risk factor in the younger group. In the ≥ 80 years age at death group, an ABCC9 gene variant (rs704180), previously associated with aging-related hippocampal sclerosis, was also associated with brain arteriolosclerosis. A post-hoc arterial spin labeling neuroimaging experiment indicated that ABCC9 genotype is associated with cerebral blood flow impairment; in a convenience sample from Alzheimer's Disease Neuroimaging Initiative (n = 15, homozygous individuals), non-risk genotype carriers showed higher global cerebral blood flow compared to risk genotype carriers. We conclude that brain arteriolosclerosis is associated with altered cognitive status and a novel vascular genetic risk factor.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - psychology</subject><subject>Arteriolosclerosis - etiology</subject><subject>Arteriolosclerosis - genetics</subject><subject>Arteriolosclerosis - psychology</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Cerebrovascular Circulation - genetics</subject><subject>Cognition</subject><subject>Databases, Factual</subject><subject>Genetic Variation</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Original</subject><subject>Risk Factors</subject><subject>Sulfonylurea Receptors - genetics</subject><issn>0271-678X</issn><issn>1559-7016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1rFTEUxYMo9lndu5Is3YwmM3PzsRGk-AWFgrTgLtyZufNMzZvUJPOg_715vFpUELq6Ied3D8k5jL2U4o2UWr8VrZZKm28SVCtB94_YRgLYRgupHrPNQW4O-gl7lvO1EMJ0AE_ZSat0ZzTIDRu_-vyDzziWmDLHZeLbEAcMfIzbxRe_J54LljXzRAELTbxEPiT0C8dUKPkYYh4DpZh95vWWwkQp3Nbj5Pd-WjHk5-zJXAe9uJun7Orjh8uzz835xacvZ-_PmxFkX5pZ9QKMGvppsGJu9TR00GM3K0QLZpYt9QjKtiBh0pashXYkA52xGpEMdqfs3dH3Zh12NI20lITB3SS_w3TrInr3t7L4724b9w461dVAqsHrO4MUf66Ui9v5PFIIuFBcs5MGbG81tOoBaKtUbwR0FRVHdKwh5UTz_YukcIca3b811pVXf_7kfuF3bxVojkDGLbnruKalJvt_w1-phqeS</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Ighodaro, Eseosa T</creator><creator>Abner, Erin L</creator><creator>Fardo, David W</creator><creator>Lin, Ai-Ling</creator><creator>Katsumata, Yuriko</creator><creator>Schmitt, Frederick A</creator><creator>Kryscio, Richard J</creator><creator>Jicha, Gregory A</creator><creator>Neltner, Janna H</creator><creator>Monsell, Sarah E</creator><creator>Kukull, Walter A</creator><creator>Moser, Debra K</creator><creator>Appiah, Frank</creator><creator>Bachstetter, Adam D</creator><creator>Van Eldik, Linda J</creator><creator>Nelson, Peter T</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20170101</creationdate><title>Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals</title><author>Ighodaro, Eseosa T ; Abner, Erin L ; Fardo, David W ; Lin, Ai-Ling ; Katsumata, Yuriko ; Schmitt, Frederick A ; Kryscio, Richard J ; Jicha, Gregory A ; Neltner, Janna H ; Monsell, Sarah E ; Kukull, Walter A ; Moser, Debra K ; Appiah, Frank ; Bachstetter, Adam D ; Van Eldik, Linda J ; Nelson, Peter T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-f640586b4db90f27db354a3f6aa958f12e4a5692515d79e9952ce853897aae8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - psychology</topic><topic>Arteriolosclerosis - etiology</topic><topic>Arteriolosclerosis - genetics</topic><topic>Arteriolosclerosis - psychology</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Cerebrovascular Circulation - genetics</topic><topic>Cognition</topic><topic>Databases, Factual</topic><topic>Genetic Variation</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Original</topic><topic>Risk Factors</topic><topic>Sulfonylurea Receptors - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ighodaro, Eseosa T</creatorcontrib><creatorcontrib>Abner, Erin L</creatorcontrib><creatorcontrib>Fardo, David W</creatorcontrib><creatorcontrib>Lin, Ai-Ling</creatorcontrib><creatorcontrib>Katsumata, Yuriko</creatorcontrib><creatorcontrib>Schmitt, Frederick A</creatorcontrib><creatorcontrib>Kryscio, Richard J</creatorcontrib><creatorcontrib>Jicha, Gregory A</creatorcontrib><creatorcontrib>Neltner, Janna H</creatorcontrib><creatorcontrib>Monsell, Sarah E</creatorcontrib><creatorcontrib>Kukull, Walter A</creatorcontrib><creatorcontrib>Moser, Debra K</creatorcontrib><creatorcontrib>Appiah, Frank</creatorcontrib><creatorcontrib>Bachstetter, Adam D</creatorcontrib><creatorcontrib>Van Eldik, Linda J</creatorcontrib><creatorcontrib>Nelson, Peter T</creatorcontrib><creatorcontrib>Alzheimer's Disease Neuroimaging Initiative (ADNI)</creatorcontrib><creatorcontrib>the Alzheimer's Disease Neuroimaging Initiative (ADNI)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cerebral blood flow and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ighodaro, Eseosa T</au><au>Abner, Erin L</au><au>Fardo, David W</au><au>Lin, Ai-Ling</au><au>Katsumata, Yuriko</au><au>Schmitt, Frederick A</au><au>Kryscio, Richard J</au><au>Jicha, Gregory A</au><au>Neltner, Janna H</au><au>Monsell, Sarah E</au><au>Kukull, Walter A</au><au>Moser, Debra K</au><au>Appiah, Frank</au><au>Bachstetter, Adam D</au><au>Van Eldik, Linda J</au><au>Nelson, Peter T</au><aucorp>Alzheimer's Disease Neuroimaging Initiative (ADNI)</aucorp><aucorp>the Alzheimer's Disease Neuroimaging Initiative (ADNI)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals</atitle><jtitle>Journal of cerebral blood flow and metabolism</jtitle><addtitle>J Cereb Blood Flow Metab</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>37</volume><issue>1</issue><spage>201</spage><epage>216</epage><pages>201-216</pages><issn>0271-678X</issn><eissn>1559-7016</eissn><abstract>Risk factors and cognitive sequelae of brain arteriolosclerosis pathology are not fully understood. To address this, we used multimodal data from the National Alzheimer's Coordinating Center and Alzheimer's Disease Neuroimaging Initiative data sets. Previous studies showed evidence of distinct neurodegenerative disease outcomes and clinical-pathological correlations in the “oldest-old” compared to younger cohorts. Therefore, using the National Alzheimer's Coordinating Center data set, we analyzed clinical and neuropathological data from two groups according to ages at death: < 80 years (n = 1008) and ≥80 years (n = 1382). In both age groups, severe brain arteriolosclerosis was associated with worse performances on global cognition tests. Hypertension (but not diabetes) was a brain arteriolosclerosis risk factor in the younger group. In the ≥ 80 years age at death group, an ABCC9 gene variant (rs704180), previously associated with aging-related hippocampal sclerosis, was also associated with brain arteriolosclerosis. A post-hoc arterial spin labeling neuroimaging experiment indicated that ABCC9 genotype is associated with cerebral blood flow impairment; in a convenience sample from Alzheimer's Disease Neuroimaging Initiative (n = 15, homozygous individuals), non-risk genotype carriers showed higher global cerebral blood flow compared to risk genotype carriers. We conclude that brain arteriolosclerosis is associated with altered cognitive status and a novel vascular genetic risk factor.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>26738751</pmid><doi>10.1177/0271678X15621574</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Aging - psychology Arteriolosclerosis - etiology Arteriolosclerosis - genetics Arteriolosclerosis - psychology Brain - pathology Brain - physiopathology Cerebrovascular Circulation - genetics Cognition Databases, Factual Genetic Variation Humans Hypertension - complications Original Risk Factors Sulfonylurea Receptors - genetics |
| title | Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals |
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