Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals

Risk factors and cognitive sequelae of brain arteriolosclerosis pathology are not fully understood. To address this, we used multimodal data from the National Alzheimer's Coordinating Center and Alzheimer's Disease Neuroimaging Initiative data sets. Previous studies showed evidence of dist...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2017-01, Vol.37 (1), p.201-216
Hauptverfasser:	Ighodaro, Eseosa T, Abner, Erin L, Fardo, David W, Lin, Ai-Ling, Katsumata, Yuriko, Schmitt, Frederick A, Kryscio, Richard J, Jicha, Gregory A, Neltner, Janna H, Monsell, Sarah E, Kukull, Walter A, Moser, Debra K, Appiah, Frank, Bachstetter, Adam D, Van Eldik, Linda J, Nelson, Peter T
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aging - psychology Arteriolosclerosis - etiology Arteriolosclerosis - genetics Arteriolosclerosis - psychology Brain - pathology Brain - physiopathology Cerebrovascular Circulation - genetics Cognition Databases, Factual Genetic Variation Humans Hypertension - complications Original Risk Factors Sulfonylurea Receptors - genetics
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Zusammenfassung:	Risk factors and cognitive sequelae of brain arteriolosclerosis pathology are not fully understood. To address this, we used multimodal data from the National Alzheimer's Coordinating Center and Alzheimer's Disease Neuroimaging Initiative data sets. Previous studies showed evidence of distinct neurodegenerative disease outcomes and clinical-pathological correlations in the “oldest-old” compared to younger cohorts. Therefore, using the National Alzheimer's Coordinating Center data set, we analyzed clinical and neuropathological data from two groups according to ages at death:
ISSN:	0271-678X 1559-7016
DOI:	10.1177/0271678X15621574