Predictors of Dyslipidemia Over Time in Youth With Type 1 Diabetes: For the SEARCH for Diabetes in Youth Study

Understanding the risk factors associated with progression and regression of dyslipidemia in youth with type 1 diabetes may guide treatments. We studied 1,478 youth with type 1 diabetes (age 10.8 ± 3.9 years, 50% male, 77% non-Hispanic white, not on lipid-lowering medications) at baseline and at a m...

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Veröffentlicht in:	Diabetes care 2017-04, Vol.40 (4), p.607-613
Hauptverfasser:	Shah, Amy S, Maahs, David M, Stafford, Jeanette M, Dolan, Lawrence M, Lang, Wei, Imperatore, Giuseppina, Bell, Ronny A, Liese, Angela D, Reynolds, Kristi, Pihoker, Catherine, Marcovina, Santica, D'Agostino, Jr, Ralph B, Dabelea, Dana
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Body Mass Index Cardiovascular and Metabolic Risk Child Children & youth Cholesterol Cholesterol, HDL - blood Cholesterol, LDL - blood Diabetes Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - complications Disease Progression Dyslipidemias - blood Dyslipidemias - complications Dyslipidemias - diagnosis Female Follow-Up Studies Glycated Hemoglobin A - metabolism Humans Lipids Logistic Models Male Medical treatment Multivariate Analysis Prospective Studies Risk Factors
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Zusammenfassung:	Understanding the risk factors associated with progression and regression of dyslipidemia in youth with type 1 diabetes may guide treatments. We studied 1,478 youth with type 1 diabetes (age 10.8 ± 3.9 years, 50% male, 77% non-Hispanic white, not on lipid-lowering medications) at baseline and at a mean follow-up of 7.1 ± 1.9 years in the SEARCH for Diabetes in Youth (SEARCH) study. Progression to dyslipidemia was defined as normal lipid concentrations at baseline and abnormal at follow-up (non-HDL-cholesterol [C] >130 mg/dL or HDL-C
ISSN:	0149-5992 1935-5548
DOI:	10.2337/dc16-2193