Vascular KATP channels mitigate severe muscle O2 delivery-utilization mismatch during contractions in chronic heart failure rats

Vascular KATP channels mitigate severe muscle O2 delivery-utilization mismatch during contractions in chronic heart failure rats

Highlights • Chronic heart failure impairs skeletal muscle microvascular oxygenation (PO2 mv) and exercise tolerance. • Vascular ATP-sensitive K+ (KATP ) channels are important modulators of muscle PO2 mv during contractions in health. • Herein we demonstrate that preserved KATP channel function hel...

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Veröffentlicht in:Respiratory physiology & neurobiology 2017-04, Vol.238, p.33-40
Hauptverfasser: Holdsworth, Clark T, Ferguson, Scott K, Colburn, Trenton D, Fees, Alexander J, Craig, Jesse C, Hirai, Daniel M, Poole, David C, Musch, Timothy I
Format: Artikel
Sprache:eng
Schlagworte:
Exercise hyperemia
Glibenclamide
Kinetics
Medical Education
Phosphorescence quenching
Pinacidil
Pulmonary/Respiratory
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Zusammenfassung:Highlights • Chronic heart failure impairs skeletal muscle microvascular oxygenation (PO2 mv) and exercise tolerance. • Vascular ATP-sensitive K+ (KATP ) channels are important modulators of muscle PO2 mv during contractions in health. • Herein we demonstrate that preserved KATP channel function helps preserve PO2 mv during muscle contractions in chronic heart failure.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2017.01.009