Emergence of a novel subclade of influenza A(H3N2) virus in London, December 2016 to January 2017

We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fel...

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Veröffentlicht in:	Euro surveillance : bulletin européen sur les maladies transmissibles 2017-02, Vol.22 (8), p.1
Hauptverfasser:	Harvala, Heli, Frampton, Dan, Grant, Paul, Raffle, Jade, Ferns, Ruth Bridget, Kozlakidis, Zisis, Kellam, Paul, Pillay, Deenan, Hayward, Andrew, Nastouli, Eleni
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Amino Acid Substitution Amino acids Child Child, Preschool Communicable Diseases, Emerging - epidemiology Communicable Diseases, Emerging - genetics Epidemics Female Genetic Drift Genetic Variation Glycosylation Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinins - genetics Humans Infant Infant, Newborn Influenza Influenza A Virus, H3N2 Subtype - classification Influenza A Virus, H3N2 Subtype - genetics Influenza A Virus, H3N2 Subtype - isolation & purification Influenza, Human - diagnosis Influenza, Human - epidemiology Influenza, Human - virology London - epidemiology Male Middle Aged Molecular Sequence Data Phylogeny Proteins Rapid Communication RNA, Viral - genetics RNA, Viral - isolation & purification Sequence Analysis, DNA Young Adult
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Zusammenfassung:	We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fell into a novel subclade (proposed as 3C.2a2); they possessed four unique amino acid substitutions in the HA protein and loss of a potential glycosylation site. These changes potentially modify the H3N2 strain antigenicity.
ISSN:	1560-7917 1025-496X 1560-7917
DOI:	10.2807/1560-7917.ES.2017.22.8.30466