Cerebellar Pathology in Early Onset and Late Onset Essential Tremor
Early onset and late onset essential tremor (ET) cases differ in several respects. Whether they differ with respect to cerebellar pathologic changes remains to be determined. We quantified a broad range of postmortem features (Purkinje cell (PC) counts, PC axonal torpedoes and associated axonal chan...
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| Veröffentlicht in: | Cerebellum (London, England) England), 2017-04, Vol.16 (2), p.473-482 |
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| creator | Kuo, Sheng-Han Wang, Jie Tate, William J. Pan, Ming-Kai Kelly, Geoffrey C. Gutierrez, Jesus Cortes, Etty P. Vonsattel, Jean-Paul G. Louis, Elan D. Faust, Phyllis L. |
| description | Early onset and late onset essential tremor (ET) cases differ in several respects. Whether they differ with respect to cerebellar pathologic changes remains to be determined. We quantified a broad range of postmortem features (Purkinje cell (PC) counts, PC axonal torpedoes and associated axonal changes, heterotopic PCs, and hairy basket ratings) in 30 ET cases with age of tremor onset |
| doi_str_mv | 10.1007/s12311-016-0826-5 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5336493</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1835398491</sourcerecordid><originalsourceid>FETCH-LOGICAL-c503t-25156b6e3768ed977341b521dc89383c1a918c93854fe2af5dbe7b6ff0066df03</originalsourceid><addsrcrecordid>eNqNkUtLAzEUhYMoPqo_wI0MuHEzmpvnzEaQUh9QqIu6DpmZO3VkOtFkKvTfm9JaqiC4yg33y7nn5hByDvQaKNU3ARgHSCmolGZMpXKPHIPQPBWM0_1tzdgROQnhjVLGqNCH5IhpzRTNxTEZDtFjgW1rffJs-1fXutkyabpkZH27TCZdwD6xXZWMbY-b6ygE7PrGtsnU49z5U3JQ2zbg2eYckJf70XT4mI4nD0_Du3FaSsr7lEmQqlDItcqwyrXmAgrJoCqznGe8BJtDVsZSihqZrWVVoC5UXVOqVFVTPiC3a933RTHHqowmvG3Nu2_m1i-Ns4352emaVzNzn0ZyrkTOo8DVRsC7jwWG3sybUK6W79AtgoFM60xoKtk_UC55nokcInr5C31zC9_Fn1gJcqUVxOEDAmuq9C4Ej_XWN1CzStOs0zQxTbNKM7oekIvdhbcvvuOLAFsDIba6Gfqd0X-qfgFp-qjL</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1873676149</pqid></control><display><type>article</type><title>Cerebellar Pathology in Early Onset and Late Onset Essential Tremor</title><source>MEDLINE</source><source>SpringerLink (Online service)</source><creator>Kuo, Sheng-Han ; Wang, Jie ; Tate, William J. ; Pan, Ming-Kai ; Kelly, Geoffrey C. ; Gutierrez, Jesus ; Cortes, Etty P. ; Vonsattel, Jean-Paul G. ; Louis, Elan D. ; Faust, Phyllis L.</creator><creatorcontrib>Kuo, Sheng-Han ; Wang, Jie ; Tate, William J. ; Pan, Ming-Kai ; Kelly, Geoffrey C. ; Gutierrez, Jesus ; Cortes, Etty P. ; Vonsattel, Jean-Paul G. ; Louis, Elan D. ; Faust, Phyllis L.</creatorcontrib><description>Early onset and late onset essential tremor (ET) cases differ in several respects. Whether they differ with respect to cerebellar pathologic changes remains to be determined. We quantified a broad range of postmortem features (Purkinje cell (PC) counts, PC axonal torpedoes and associated axonal changes, heterotopic PCs, and hairy basket ratings) in 30 ET cases with age of tremor onset <50 years, 30 ET cases with age of tremor onset ≥50 years, and 30 controls (total
n
= 90). We also used two alternative age of onset cut-points (<40 vs. ≥40 years, and <60 vs. ≥60 years) to define early onset vs. late onset ET. We found that ET cases with tremor onset <50 years and tremor onset ≥50 years had similar PC counts (8.78 ± 1.70 vs. 8.86 ± 1.24,
p
= 0.839), PC axonal torpedo counts (17.87 ± 18.27 [median =13.00] vs. 12.90 ± 10.60 [median =9.0],
p
= 0.486) and associated axonal pathology (all
p
values >0.05), heterotopic PC counts (9.90 ± 11.55 [median =6.00] vs. 5.40 ± 5.10 [median =3.50],
p
= 0.092), and hairy basket ratings (1.95 ± 0.62 [median =2.00] vs. 2.05 ± 0.92 [median =2.00],
p
= 0.314). When using the age of onset cut-points of 40 or 60 years, results were similar. Early onset and late onset ET cases share similar cerebellar postmortem features. These data do not support the notion that these age-of-onset related forms of ET represent distinct clinical-pathological entities.</description><identifier>ISSN: 1473-4222</identifier><identifier>EISSN: 1473-4230</identifier><identifier>DOI: 10.1007/s12311-016-0826-5</identifier><identifier>PMID: 27726094</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Age of Onset ; Aged, 80 and over ; Biomedical and Life Sciences ; Biomedicine ; Cerebellum - pathology ; Essential Tremor - pathology ; Female ; Humans ; Male ; Neurobiology ; Neurology ; Neurosciences ; Original Paper ; Prospective Studies</subject><ispartof>Cerebellum (London, England), 2017-04, Vol.16 (2), p.473-482</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>The Cerebellum is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-25156b6e3768ed977341b521dc89383c1a918c93854fe2af5dbe7b6ff0066df03</citedby><cites>FETCH-LOGICAL-c503t-25156b6e3768ed977341b521dc89383c1a918c93854fe2af5dbe7b6ff0066df03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12311-016-0826-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12311-016-0826-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27726094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuo, Sheng-Han</creatorcontrib><creatorcontrib>Wang, Jie</creatorcontrib><creatorcontrib>Tate, William J.</creatorcontrib><creatorcontrib>Pan, Ming-Kai</creatorcontrib><creatorcontrib>Kelly, Geoffrey C.</creatorcontrib><creatorcontrib>Gutierrez, Jesus</creatorcontrib><creatorcontrib>Cortes, Etty P.</creatorcontrib><creatorcontrib>Vonsattel, Jean-Paul G.</creatorcontrib><creatorcontrib>Louis, Elan D.</creatorcontrib><creatorcontrib>Faust, Phyllis L.</creatorcontrib><title>Cerebellar Pathology in Early Onset and Late Onset Essential Tremor</title><title>Cerebellum (London, England)</title><addtitle>Cerebellum</addtitle><addtitle>Cerebellum</addtitle><description>Early onset and late onset essential tremor (ET) cases differ in several respects. Whether they differ with respect to cerebellar pathologic changes remains to be determined. We quantified a broad range of postmortem features (Purkinje cell (PC) counts, PC axonal torpedoes and associated axonal changes, heterotopic PCs, and hairy basket ratings) in 30 ET cases with age of tremor onset <50 years, 30 ET cases with age of tremor onset ≥50 years, and 30 controls (total
n
= 90). We also used two alternative age of onset cut-points (<40 vs. ≥40 years, and <60 vs. ≥60 years) to define early onset vs. late onset ET. We found that ET cases with tremor onset <50 years and tremor onset ≥50 years had similar PC counts (8.78 ± 1.70 vs. 8.86 ± 1.24,
p
= 0.839), PC axonal torpedo counts (17.87 ± 18.27 [median =13.00] vs. 12.90 ± 10.60 [median =9.0],
p
= 0.486) and associated axonal pathology (all
p
values >0.05), heterotopic PC counts (9.90 ± 11.55 [median =6.00] vs. 5.40 ± 5.10 [median =3.50],
p
= 0.092), and hairy basket ratings (1.95 ± 0.62 [median =2.00] vs. 2.05 ± 0.92 [median =2.00],
p
= 0.314). When using the age of onset cut-points of 40 or 60 years, results were similar. Early onset and late onset ET cases share similar cerebellar postmortem features. These data do not support the notion that these age-of-onset related forms of ET represent distinct clinical-pathological entities.</description><subject>Age of Onset</subject><subject>Aged, 80 and over</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cerebellum - pathology</subject><subject>Essential Tremor - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Prospective Studies</subject><issn>1473-4222</issn><issn>1473-4230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkUtLAzEUhYMoPqo_wI0MuHEzmpvnzEaQUh9QqIu6DpmZO3VkOtFkKvTfm9JaqiC4yg33y7nn5hByDvQaKNU3ARgHSCmolGZMpXKPHIPQPBWM0_1tzdgROQnhjVLGqNCH5IhpzRTNxTEZDtFjgW1rffJs-1fXutkyabpkZH27TCZdwD6xXZWMbY-b6ygE7PrGtsnU49z5U3JQ2zbg2eYckJf70XT4mI4nD0_Du3FaSsr7lEmQqlDItcqwyrXmAgrJoCqznGe8BJtDVsZSihqZrWVVoC5UXVOqVFVTPiC3a933RTHHqowmvG3Nu2_m1i-Ns4352emaVzNzn0ZyrkTOo8DVRsC7jwWG3sybUK6W79AtgoFM60xoKtk_UC55nokcInr5C31zC9_Fn1gJcqUVxOEDAmuq9C4Ej_XWN1CzStOs0zQxTbNKM7oekIvdhbcvvuOLAFsDIba6Gfqd0X-qfgFp-qjL</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Kuo, Sheng-Han</creator><creator>Wang, Jie</creator><creator>Tate, William J.</creator><creator>Pan, Ming-Kai</creator><creator>Kelly, Geoffrey C.</creator><creator>Gutierrez, Jesus</creator><creator>Cortes, Etty P.</creator><creator>Vonsattel, Jean-Paul G.</creator><creator>Louis, Elan D.</creator><creator>Faust, Phyllis L.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170401</creationdate><title>Cerebellar Pathology in Early Onset and Late Onset Essential Tremor</title><author>Kuo, Sheng-Han ; Wang, Jie ; Tate, William J. ; Pan, Ming-Kai ; Kelly, Geoffrey C. ; Gutierrez, Jesus ; Cortes, Etty P. ; Vonsattel, Jean-Paul G. ; Louis, Elan D. ; Faust, Phyllis L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-25156b6e3768ed977341b521dc89383c1a918c93854fe2af5dbe7b6ff0066df03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age of Onset</topic><topic>Aged, 80 and over</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cerebellum - pathology</topic><topic>Essential Tremor - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Neurobiology</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Original Paper</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuo, Sheng-Han</creatorcontrib><creatorcontrib>Wang, Jie</creatorcontrib><creatorcontrib>Tate, William J.</creatorcontrib><creatorcontrib>Pan, Ming-Kai</creatorcontrib><creatorcontrib>Kelly, Geoffrey C.</creatorcontrib><creatorcontrib>Gutierrez, Jesus</creatorcontrib><creatorcontrib>Cortes, Etty P.</creatorcontrib><creatorcontrib>Vonsattel, Jean-Paul G.</creatorcontrib><creatorcontrib>Louis, Elan D.</creatorcontrib><creatorcontrib>Faust, Phyllis L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cerebellum (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuo, Sheng-Han</au><au>Wang, Jie</au><au>Tate, William J.</au><au>Pan, Ming-Kai</au><au>Kelly, Geoffrey C.</au><au>Gutierrez, Jesus</au><au>Cortes, Etty P.</au><au>Vonsattel, Jean-Paul G.</au><au>Louis, Elan D.</au><au>Faust, Phyllis L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebellar Pathology in Early Onset and Late Onset Essential Tremor</atitle><jtitle>Cerebellum (London, England)</jtitle><stitle>Cerebellum</stitle><addtitle>Cerebellum</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>16</volume><issue>2</issue><spage>473</spage><epage>482</epage><pages>473-482</pages><issn>1473-4222</issn><eissn>1473-4230</eissn><abstract>Early onset and late onset essential tremor (ET) cases differ in several respects. Whether they differ with respect to cerebellar pathologic changes remains to be determined. We quantified a broad range of postmortem features (Purkinje cell (PC) counts, PC axonal torpedoes and associated axonal changes, heterotopic PCs, and hairy basket ratings) in 30 ET cases with age of tremor onset <50 years, 30 ET cases with age of tremor onset ≥50 years, and 30 controls (total
n
= 90). We also used two alternative age of onset cut-points (<40 vs. ≥40 years, and <60 vs. ≥60 years) to define early onset vs. late onset ET. We found that ET cases with tremor onset <50 years and tremor onset ≥50 years had similar PC counts (8.78 ± 1.70 vs. 8.86 ± 1.24,
p
= 0.839), PC axonal torpedo counts (17.87 ± 18.27 [median =13.00] vs. 12.90 ± 10.60 [median =9.0],
p
= 0.486) and associated axonal pathology (all
p
values >0.05), heterotopic PC counts (9.90 ± 11.55 [median =6.00] vs. 5.40 ± 5.10 [median =3.50],
p
= 0.092), and hairy basket ratings (1.95 ± 0.62 [median =2.00] vs. 2.05 ± 0.92 [median =2.00],
p
= 0.314). When using the age of onset cut-points of 40 or 60 years, results were similar. Early onset and late onset ET cases share similar cerebellar postmortem features. These data do not support the notion that these age-of-onset related forms of ET represent distinct clinical-pathological entities.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27726094</pmid><doi>10.1007/s12311-016-0826-5</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age of Onset Aged, 80 and over Biomedical and Life Sciences Biomedicine Cerebellum - pathology Essential Tremor - pathology Female Humans Male Neurobiology Neurology Neurosciences Original Paper Prospective Studies |
| title | Cerebellar Pathology in Early Onset and Late Onset Essential Tremor |
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