Aberrant Epicardial Adipose Tissue Extracellular Matrix Remodeling in Patients with Severe Ischemic Cardiomyopathy: Insight from Comparative Quantitative Proteomics

There is ample evidence indicating that epicardial adipose tissue (EAT) volume and thickness is positively associated with coronary artery disease (CAD). However, the exact pathological changes in the human EAT after myocardial ischemia remains largely unclear. In the current study, we applied a com...

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Veröffentlicht in:	Scientific reports 2017-03, Vol.7 (1), p.43787-43787, Article 43787
Hauptverfasser:	Jiang, Ding-Sheng, Zeng, Hao-Long, Li, Rui, Huo, Bo, Su, Yun-Shu, Fang, Jing, Yang, Qing, Liu, Li-Gang, Hu, Min, Cheng, Cai, Zhu, Xue-Hai, Yi, Xin, Wei, Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 692/4019/592 692/420 82/80 Adipose tissue Cardiomyocytes Cardiomyopathy Cardiovascular disease Collagen Coronary artery Extracellular matrix Gluconeogenesis Glycolysis Heart diseases Humanities and Social Sciences Ischemia multidisciplinary Myocardial ischemia Peroxisome proliferator-activated receptors Proteins Proteomics Science Signal transduction
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Zusammenfassung:	There is ample evidence indicating that epicardial adipose tissue (EAT) volume and thickness is positively associated with coronary artery disease (CAD). However, the exact pathological changes in the human EAT after myocardial ischemia remains largely unclear. In the current study, we applied a comparative quantitative proteomics to elucidate the altered biological processes in the EAT of ischemic cardiomyopathy (ICM) patients. A total of 1649 proteins were successfully quantified in our study, among which 165 proteins were significantly changed (ratio 1.2 fold and p
ISSN:	2045-2322 2045-2322
DOI:	10.1038/srep43787