Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis

Lipoma preferred partner ( ) and T-cell activation Rho GTPase activating protein ( ) polymorphisms might influence the susceptibility to celiac disease. Therefore, we performed a meta-analysis by identifying relevant studies to estimate the risks of these polymorphisms on celiac disease. The PubMed, Web of Science and Embase databases were searched (up to October 2016) for rs1464510 and rs1738074 polymorphisms. This meta-analysis included the same 7 studies for rs1464510 and rs1738074. The minor risk A allele at both rs1464510 and rs1738074 carried risks (odds ratios) of 1.26 (95% CI: 1.22-1.30) and 1.17 (95% CI: 1.14-1.21), respectively, which contributed to increased risks in all celiac disease patients by 10.72% and 6.59%, respectively. The estimated lambdas were 0.512 and 0.496, respectively, suggesting that a co-dominant model would be suitable for both gene effects. This meta-analysis provides robust estimates that polymorphisms in and genes are potential risk factors for celiac disease in European and American. Prospective studies and more genome-wide association studies (GWAS) are needed to confirm these findings, and some corresponding molecular biology experiments should be carried out to clarify the pathogenic mechanisms of celiac disease.