Understanding the Intersections between Metabolism and Cancer Biology

Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining th...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cell 2017-02, Vol.168 (4), p.657-669
Hauptverfasser: Vander Heiden, Matthew G., DeBerardinis, Ralph J.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining the pathways that are limiting for cancer progression and understanding the context specificity of metabolic preferences and liabilities in malignant cells. Progress toward answering these questions is providing new insight into cancer biology and can guide the more effective targeting of metabolism to help patients. Emerging evidence highlights the diverse paths for metabolic activities to contribute to cancer development and therapeutic resistance. Understanding the context specificity in the multilayer complexity of cancer metabolism may guide future development in cancer treatment.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2016.12.039