Bidentate iminodiacetate modified dendrimer for bone imaging

Bidentate iminodiacetate modified dendrimer for bone imaging

[Display omitted] A new dendrimer probe was designed for bone imaging. Bidentate iminodiacetate groups were introduced to the probe to obtain strong bind to bones. The assembled dendrimeric probe, with four iminodiacetate moieties and a fluorescent tag, displayed good selectivity to hydroxyapatite,...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2017-03, Vol.27 (5), p.1252-1255
Hauptverfasser: Pes, Lara, Kim, Young, Tung, Ching-Hsuan
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Intravenous
Animals
Bone
Bone and Bones - diagnostic imaging
Dendrimer
Dendrimers - chemistry
Diagnostic Imaging
Fluorescence imaging
Fluorescent Dyes - chemistry
Hydroxyapatite
Imino Acids - chemistry
Iminodiacetate
Mice
Molecular Structure
Polylysine - chemical synthesis
Polylysine - chemistry
Polylysine - pharmacology
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Zusammenfassung:[Display omitted] A new dendrimer probe was designed for bone imaging. Bidentate iminodiacetate groups were introduced to the probe to obtain strong bind to bones. The assembled dendrimeric probe, with four iminodiacetate moieties and a fluorescent tag, displayed good selectivity to hydroxyapatite, calcium oxalate and calcium phosphate salts. In mice, the probe offered vivid skeletal details after intravenous delivery.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2017.01.059