Circulating Tumor DNA as a Cancer Biomarker: Fact or Fiction?

[...]in those cases where both can be detected, the level of ctDNA is 1-2 orders of magnitude greater than that present in circulating tumor cells. [...]advanced cases of cancer are often associated with increased concentrations of cfDNA from normal cells, presumably due to death and destruction of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2016-08, Vol.62 (8), p.1054-1060
Hauptverfasser:	Leung, Felix, Kulasingam, Vathany, Diamandis, Eleftherios P, Hoon, Dave S B, Kinzler, Kenneth, Pantel, Klaus, Alix-Panabières, Catherine
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biomarkers Biomarkers, Tumor - analysis Circulating Tumor DNA - analysis Conflicts of interest Deoxyribonucleic acid DNA Gangrene Genomes Human health and pathology Humans Life Sciences Mammography Metastasis Neoplasms - pathology Neoplastic Cells, Circulating - pathology Prostate cancer Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	[...]in those cases where both can be detected, the level of ctDNA is 1-2 orders of magnitude greater than that present in circulating tumor cells. [...]advanced cases of cancer are often associated with increased concentrations of cfDNA from normal cells, presumably due to death and destruction of normal cells in the tumor beds.
ISSN:	0009-9147 1530-8561
DOI:	10.1373/clinchem.2016.260331