Reparative Effects of Interleukin-1 Receptor Antagonist in Young And Aged/Co-Morbid Rodents After Cerebral Ischemia
Highlights • IL-1β is a key proinflammatory cytokine involved in ischemic brain damage. • Administration of IL-1Ra improves the stroke outcome in young and co-morbid rats. • Acute IL-1Ra administration also promotes neurogenesis after experimental stroke.
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| Veröffentlicht in: | Brain, behavior, and immunity behavior, and immunity, 2017-03, Vol.61, p.117-126 |
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| container_end_page | 126 |
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| container_start_page | 117 |
| container_title | Brain, behavior, and immunity |
| container_volume | 61 |
| creator | Pradillo, Jesus.M Murray, Katie N Coutts, Graham A Moraga, Ana Oroz-Gonjar, Fernando Boutin, Herve Moro, Maria A Lizasoain, Ignacio Rothwell, Nancy J Allan, Stuart M |
| description | Highlights • IL-1β is a key proinflammatory cytokine involved in ischemic brain damage. • Administration of IL-1Ra improves the stroke outcome in young and co-morbid rats. • Acute IL-1Ra administration also promotes neurogenesis after experimental stroke. |
| doi_str_mv | 10.1016/j.bbi.2016.11.013 |
| format | Article |
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| ispartof | Brain, behavior, and immunity, 2017-03, Vol.61, p.117-126 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Allergy and Immunology Animals Brain - drug effects Brain Ischemia - drug therapy Cell Movement - drug effects Cerebral ischemia Co-morbidity Full-length Interleukin 1 Receptor Antagonist Protein - pharmacology Interleukin 1 Receptor Antagonist Protein - therapeutic use Interleukin-1 receptor antagonist Male Neurogenesis Neurogenesis - drug effects Neurons - drug effects Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Psychiatry Rats Rats, Wistar Risk factors Stroke - drug therapy Time Factors |
| title | Reparative Effects of Interleukin-1 Receptor Antagonist in Young And Aged/Co-Morbid Rodents After Cerebral Ischemia |
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