Reparative Effects of Interleukin-1 Receptor Antagonist in Young And Aged/Co-Morbid Rodents After Cerebral Ischemia

Highlights • IL-1β is a key proinflammatory cytokine involved in ischemic brain damage. • Administration of IL-1Ra improves the stroke outcome in young and co-morbid rats. • Acute IL-1Ra administration also promotes neurogenesis after experimental stroke.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2017-03, Vol.61, p.117-126
Hauptverfasser:	Pradillo, Jesus.M, Murray, Katie N, Coutts, Graham A, Moraga, Ana, Oroz-Gonjar, Fernando, Boutin, Herve, Moro, Maria A, Lizasoain, Ignacio, Rothwell, Nancy J, Allan, Stuart M
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Brain - drug effects Brain Ischemia - drug therapy Cell Movement - drug effects Cerebral ischemia Co-morbidity Full-length Interleukin 1 Receptor Antagonist Protein - pharmacology Interleukin 1 Receptor Antagonist Protein - therapeutic use Interleukin-1 receptor antagonist Male Neurogenesis Neurogenesis - drug effects Neurons - drug effects Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Psychiatry Rats Rats, Wistar Risk factors Stroke - drug therapy Time Factors
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Beschreibung
Zusammenfassung:	Highlights • IL-1β is a key proinflammatory cytokine involved in ischemic brain damage. • Administration of IL-1Ra improves the stroke outcome in young and co-morbid rats. • Acute IL-1Ra administration also promotes neurogenesis after experimental stroke.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.11.013