Sequential Double “Clicks” toward Structurally Well‐Defined Heterogeneous N‐Glycoclusters: The Importance of Cluster Heterogeneity on Pattern Recognition In Vivo

Sequential Double “Clicks” toward Structurally Well‐Defined Heterogeneous N‐Glycoclusters: The Importance of Cluster Heterogeneity on Pattern Recognition In Vivo

Structurally well‐defined heterogeneous N‐glycoclusters are prepared on albumin via a double click procedure. The number of glycan molecules present, in addition to the spatial arrangement of glycans in the heterogeneous glycoclusters, plays an important role in the in vivo kinetics and organ‐select...

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Veröffentlicht in:Advanced science 2017-02, Vol.4 (2), p.1600394-n/a
Hauptverfasser: Latypova, Liliya, Sibgatullina, Regina, Ogura, Akihiro, Fujiki, Katsumasa, Khabibrakhmanova, Alsu, Tahara, Tsuyoshi, Nozaki, Satoshi, Urano, Sayaka, Tsubokura, Kazuki, Onoe, Hirotaka, Watanabe, Yasuyoshi, Kurbangalieva, Almira, Tanaka, Katsunori
Format: Artikel
Sprache:eng
Schlagworte:
Abdomen
Acids
Azide
biodistribution
Communication
Communications
Gallbladder
heterogeneity
in vivo kinetics
Kinetics
Liver
noninvasive fluorescence imaging
N‐glycoalbumin
Pattern recognition
Proteins
Signal transduction
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Zusammenfassung:Structurally well‐defined heterogeneous N‐glycoclusters are prepared on albumin via a double click procedure. The number of glycan molecules present, in addition to the spatial arrangement of glycans in the heterogeneous glycoclusters, plays an important role in the in vivo kinetics and organ‐selective accumulation through glycan pattern recognition mechanisms.
ISSN:2198-3844
2198-3844
DOI:10.1002/advs.201600394