Evidence for Critical Role of Lymphocyte Cytosolic Protein 1 in Oral Cancer

Lymphocyte cytosolic protein 1 (LCP1), a member of actin-binding protein of the plastin family, has been identified in several malignant tumors of non-hematopoietic sites, such as the colon, prostate, and breast. However, little is known about the roles of LCP1 in oral squamous cell carcinomas (OSCC...

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Veröffentlicht in:	Scientific reports 2017-02, Vol.7 (1), p.43379-43379, Article 43379
Hauptverfasser:	Koide, Nao, Kasamatsu, Atsushi, Endo-Sakamoto, Yosuke, Ishida, Sho, Shimizu, Toshihiro, Kimura, Yasushi, Miyamoto, Isao, Yoshimura, Shusaku, Shiiba, Masashi, Tanzawa, Hideki, Uzawa, Katsuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1665 631/67/1857 82/51 82/80 Actin Aged Antineoplastic Agents - pharmacology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - pathology Cell Line, Tumor Cell migration Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Colon Enoxacin Enoxacin - pharmacology Female Gene Expression Regulation, Neoplastic Humanities and Social Sciences Humans Immunoblotting Immunohistochemistry Invasiveness Lymph Lymph nodes Lymph Nodes - immunology Lymph Nodes - pathology Lymphatic Metastasis Lymphocytes Male Metastases Microfilament Proteins - antagonists & inhibitors Microfilament Proteins - genetics Microfilament Proteins - immunology Middle Aged Mouth Neoplasms - genetics Mouth Neoplasms - immunology Mouth Neoplasms - pathology multidisciplinary Neoplasm Invasiveness Neoplasm Staging Oral cancer Oral carcinoma Oral squamous cell carcinoma Polymerase chain reaction Prostate Proteins Reverse transcription RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Science Squamous cell carcinoma T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - pathology Therapeutic applications Tumor Burden Tumors
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Zusammenfassung:	Lymphocyte cytosolic protein 1 (LCP1), a member of actin-binding protein of the plastin family, has been identified in several malignant tumors of non-hematopoietic sites, such as the colon, prostate, and breast. However, little is known about the roles of LCP1 in oral squamous cell carcinomas (OSCCs). This present study sought to clarify the clinical relevance of LCP1 in OSCCs and investigate possible clinical applications for treating OSCCs by regulating LCP1 expression. We found up-regulation of LCP1in OSCCs compared with normal counterparts using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR), immunoblotting, and immunohistochemistry ( P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/srep43379