Regulation of prostate cancer progression by the tumor microenvironment

Highlights • Both innate and adaptive immune cells contribute to prostate cancer progression. • Non-immune and immune stroma regulate each other and their effect on tumor cells. • Stromal cells exert their influence via direct cell-to-cell contact, soluble factors and extracellular vesicles.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2016-09, Vol.380 (1), p.340-348
Hauptverfasser:	Shiao, Stephen L, Chu, Gina Chia-Yi, Chung, Leland W.K
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Cell Communication Cell Movement Cellular Reprogramming Cytokines Dendritic cells Exosomes Fibroblasts Hematology, Oncology and Palliative Medicine Humans Inflammation - metabolism Inflammation - pathology Inflammation Mediators - metabolism Lymphocytes Male Metastasis Metastasis-initiating cells microRNA Neoplasm Metastasis Neoplastic Cells, Circulating - immunology Neoplastic Cells, Circulating - metabolism Neoplastic Cells, Circulating - pathology Phenotype Prostate cancer Prostatic Neoplasms - immunology Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Signal Transduction Stem cells Stromal Cells - metabolism Stromal Cells - pathology Tumor immune microenvironment Tumor Microenvironment Tumorigenesis Tumors
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Beschreibung
Zusammenfassung:	Highlights • Both innate and adaptive immune cells contribute to prostate cancer progression. • Non-immune and immune stroma regulate each other and their effect on tumor cells. • Stromal cells exert their influence via direct cell-to-cell contact, soluble factors and extracellular vesicles.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2015.12.022