Achilles is a circadian clock-controlled gene that regulates immune function in Drosophila

Highlights • Achilles is a clock-controlled gene. • Achilles represses expression of immune responsive genes in Drosophila. • Neurons in the fly brain coordinate immune responses in Drosophila. • The regulation of immunity by circadian clocks is accessible to molecular genetic investigation using Dr...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2017-03, Vol.61, p.127-136
Hauptverfasser:	Li, Jiajia, Terry, Erin E, Fejer, Edith, Gamba, Diana, Hartmann, Natalie, Logsdon, Joseph, Michalski, Daniel, Rois, Lisa E, Scuderi, Maria J, Kunst, Michael, Hughes, Michael E
Format:	Artikel
Sprache:	eng
Schlagworte:	Achilles Allergy and Immunology Animals Antimicrobial peptides Bacterial infection CG17386 Circadian clock Circadian Clocks - genetics Circadian Rhythm - genetics CLOCK Proteins - genetics Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - immunology Drosophila Proteins - genetics Fat body Gene expression Genomics Immune System - immunology Immunity Neurons - immunology Psychiatry RNA-binding protein RNA-seq Signal Transduction - genetics
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Beschreibung
Zusammenfassung:	Highlights • Achilles is a clock-controlled gene. • Achilles represses expression of immune responsive genes in Drosophila. • Neurons in the fly brain coordinate immune responses in Drosophila. • The regulation of immunity by circadian clocks is accessible to molecular genetic investigation using Drosophila.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.11.012