Timing temporal transitions during brain development

Timing temporal transitions during brain development

Highlights • Temporal patterning of neural progenitors is a conserved strategy to generate cell diversity. • In Drosophila , tTFs deterministically regulate cell fate. • In vertebrates, tTFs bias stochastic cell-fate decisions towards specific fates. • Intrinsic and extrinsic cues can regulate tempo...

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Veröffentlicht in:Current opinion in neurobiology 2017-02, Vol.42, p.84-92
Hauptverfasser: Rossi, Anthony M, Fernandes, Vilaiwan M, Desplan, Claude
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological Evolution
Brain - cytology
Brain - embryology
Invertebrates - embryology
Neural Stem Cells - cytology
Neurology
Neurons - cytology
Psychiatry
Time Factors
Vertebrates - embryology
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Zusammenfassung:Highlights • Temporal patterning of neural progenitors is a conserved strategy to generate cell diversity. • In Drosophila , tTFs deterministically regulate cell fate. • In vertebrates, tTFs bias stochastic cell-fate decisions towards specific fates. • Intrinsic and extrinsic cues can regulate temporal transitions.
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2016.11.010