Effects of Ibuprofen on Cognition and NMDA Receptor Subunit Expression Across Aging

Highlights • Ibuprofen enhanced executive function more than memory in a short-term memory task. • Ibuprofen decreased expression of several NMDA receptor subunits across adult aging. • Ibuprofen increased expression of GluN1-3 splice form mRNA and C2' cassette protein in frontal lobes regardle...

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Veröffentlicht in:	Neuroscience 2017-03, Vol.344, p.276-292
Hauptverfasser:	Márquez Loza, Alejandra, Elias, Valerie, Wong, Carmen P, Ho, Emily, Bermudez, Michelle, Magnusson, Kathy R
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Aging - drug effects Aging - metabolism Aging - pathology Aging - psychology Alternative Splicing Animals anti-inflammatory Anti-Inflammatory Agents, Non-Steroidal - pharmacology Astrocytes - drug effects Astrocytes - metabolism Astrocytes - pathology Brain - drug effects Brain - metabolism Brain - pathology Cognition - drug effects Cognition - physiology Cytokines - metabolism executive function Executive Function - drug effects Executive Function - physiology Gliosis - drug therapy Gliosis - metabolism Gliosis - pathology Ibuprofen - pharmacology Male Maze Learning - drug effects Maze Learning - physiology Memory, Long-Term - drug effects Memory, Long-Term - physiology Memory, Short-Term - drug effects Memory, Short-Term - physiology Mice, Inbred C57BL N-methyl-d-aspartate receptor Neurology Nootropic Agents - pharmacology Random Allocation Receptors, N-Methyl-D-Aspartate - metabolism RNA, Messenger - metabolism Spatial Memory - drug effects Spatial Memory - physiology Spleen - drug effects Spleen - metabolism
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Zusammenfassung:	Highlights • Ibuprofen enhanced executive function more than memory in a short-term memory task. • Ibuprofen decreased expression of several NMDA receptor subunits across adult aging. • Ibuprofen increased expression of GluN1-3 splice form mRNA and C2' cassette protein in frontal lobes regardless of age. • Ibuprofen did not alter expression of pro-inflammatory cytokines, but reduced gliosis in frontal cortex of aged mice. • Enhancement in executive function was related to increased GluN1-3 mRNA and decreased gliosis.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.12.041