Nanoformulation of synergistic TLR ligands to enhance vaccination against Entamoeba histolytica

Highlights • Nanoliposome adjuvant induced a robust mucosal and systemic response towards an amebiasis antigen. • Vaccine induced mucosal IgA inhibited adherence of E. histolytica to target cells in vitro. • This adjuvant is compatible with the use of all-trans retinoic acid as a co-adjuvant. • The...

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Veröffentlicht in:	Vaccine 2017-02, Vol.35 (6), p.916-922
Hauptverfasser:	Abhyankar, Mayuresh M, Noor, Zannatun, Tomai, Mark A, Elvecrog, James, Fox, Christopher B, Petri, William A
Format:	Artikel
Sprache:	eng
Schlagworte:	adjuvants Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - chemistry agonists Allergy and Immunology alum Alum Compounds - administration & dosage Amebiasis Animals Antibodies, Protozoan - biosynthesis Antigens Antigens, Protozoan - chemistry Antigens, Protozoan - immunology Aqueous solutions Cytokines diarrhea emulsions Entamoeba Entamoeba histolytica Entamoeba histolytica - drug effects Entamoeba histolytica - growth & development Entamoeba histolytica - immunology Entamoebiasis - immunology Entamoebiasis - parasitology Entamoebiasis - prevention & control enteropathogens Experiments Immune response Immunity, Mucosal - drug effects Immunization immunoglobulin A Infectious diseases interferon-gamma Interferon-gamma - biosynthesis Interferon-gamma - immunology interleukin-17 Interleukin-17 - biosynthesis Interleukin-17 - immunology Lectins Lectins - chemistry Lectins - immunology Ligands Lipopolysaccharides - administration & dosage Liposome Liposomes - administration & dosage Liposomes - chemistry Liposomes - immunology Membrane Glycoproteins - agonists Membrane Glycoproteins - genetics Membrane Glycoproteins - immunology Mice Mice, Inbred CBA morbidity mortality mucosal immunity Oligodeoxyribonucleotides - administration & dosage Parasites Pathogens Polysorbates - administration & dosage Protozoan Vaccines - administration & dosage Protozoan Vaccines - chemistry Protozoan Vaccines - immunology retinoic acid RNA - administration & dosage Squalene - administration & dosage Studies subunit vaccines Toll-Like Receptor 3 - agonists Toll-Like Receptor 3 - genetics Toll-Like Receptor 3 - immunology Toll-like receptor 4 Toll-Like Receptor 7 - agonists Toll-Like Receptor 7 - genetics Toll-Like Receptor 7 - immunology Toll-Like Receptor 8 - agonists Toll-Like Receptor 8 - genetics Toll-Like Receptor 8 - immunology Tretinoin - administration & dosage Tropical diseases vaccination Vaccine vaccine development Vaccines Vaccines, Subunit
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Beschreibung
Zusammenfassung:	Highlights • Nanoliposome adjuvant induced a robust mucosal and systemic response towards an amebiasis antigen. • Vaccine induced mucosal IgA inhibited adherence of E. histolytica to target cells in vitro. • This adjuvant is compatible with the use of all-trans retinoic acid as a co-adjuvant. • The adjuvant showed potential to elicit protective response against E. histolytica.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2016.12.057