Pharmacokinetics and exposure–effect relationships of capecitabine in elderly patients with breast or colorectal cancer

Purpose The aims of the present study were (1) to investigate the impact of great age on pharmacokinetics of capecitabine and its metabolites and (2) to evaluate the exposure–effect relationship of capecitabine in elderly patients. Methods Data collected from 20 elderly patients (75–92 years old) wi...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2014-06, Vol.73 (6), p.1285-1293
Hauptverfasser:	Daher Abdi, Z., Lavau-Denes, S., Prémaud, A., Urien, S., Sauvage, F. L., Martin, J., Leobon, S., Marquet, P., Tubiana-Mathieu, N., Rousseau, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Aged, 80 and over Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - adverse effects Antimetabolites, Antineoplastic - pharmacokinetics Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Research Capecitabine Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Deoxycytidine - administration & dosage Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacokinetics Female Fluorouracil - administration & dosage Fluorouracil - adverse effects Fluorouracil - analogs & derivatives Fluorouracil - pharmacokinetics Gastroenterology. Liver. Pancreas. Abdomen Gynecology. Andrology. Obstetrics Humans Male Mammary gland diseases Medical sciences Medicine Medicine & Public Health Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Oncology Original Article Pharmacology. Drug treatments Pharmacology/Toxicology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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Zusammenfassung:	Purpose The aims of the present study were (1) to investigate the impact of great age on pharmacokinetics of capecitabine and its metabolites and (2) to evaluate the exposure–effect relationship of capecitabine in elderly patients. Methods Data collected from 20 elderly patients (75–92 years old) with breast or colorectal cancer who received oral capecitabine were analyzed. In order to study the old age effect on pharmacokinetics, data collected from two phase I studies involving 40 younger adults (
ISSN:	0344-5704 1432-0843
DOI:	10.1007/s00280-014-2466-0