Cortical Morphogenesis during Embryonic Development Is Regulated by miR-34c and miR-204

Cortical Morphogenesis during Embryonic Development Is Regulated by miR-34c and miR-204

The porcine brain closely resembles the human brain in aspects such as development and morphology. Temporal miRNA profiling in the developing embryonic porcine cortex revealed a distinct set of miRNAs, including miR-34c and miR-204, which exhibited a highly specific expression profile across the tim...

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Veröffentlicht in:Frontiers in molecular neuroscience 2017-02, Vol.10, p.31-31
Hauptverfasser: Venø, Morten T, Venø, Susanne T, Rehberg, Kati, van Asperen, Jessy V, Clausen, Bettina H, Holm, Ida E, Pasterkamp, R Jeroen, Finsen, Bente, Kjems, Jørgen
Format: Artikel
Sprache:eng
Schlagworte:
Cell division
Cell migration
Cytoskeleton
Doublecortin protein
Embryogenesis
Epilepsy
Gene expression
Kinases
Mammals
MicroRNAs
miRNA
Morphogenesis
Mutation
Neurons
Neuroscience
Post-transcription
Proteins
Temporal cortex
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Zusammenfassung:The porcine brain closely resembles the human brain in aspects such as development and morphology. Temporal miRNA profiling in the developing embryonic porcine cortex revealed a distinct set of miRNAs, including miR-34c and miR-204, which exhibited a highly specific expression profile across the time of cortical folding. These miRNAs were found to target Doublecortin (DCX), known to be involved in neuron migration during cortical folding of gyrencephalic brains. modulation of miRNA expression in mouse embryos confirmed that miR-34c and miR-204 can control neuronal migration and cortical morphogenesis, presumably by posttranscriptional regulation of DCX.
ISSN:1662-5099
1662-5099
DOI:10.3389/fnmol.2017.00031