Serum selenium levels and prostate cancer risk: A MOOSE-compliant meta-analysis
Some observational studies have shown that elevated serum selenium levels are associated with reduced prostate cancer risk; however, not all published studies support these results. A literature search of PubMed, Embase, Medline, and the Cochrane Library up until September 2016 identified 17 studies...
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| Veröffentlicht in: | Medicine (Baltimore) 2017-02, Vol.96 (5), p.e5944-e5944 |
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| creator | Cui, Zhigang Liu, Dezhong Liu, Chun Liu, Gang |
| description | Some observational studies have shown that elevated serum selenium levels are associated with reduced prostate cancer risk; however, not all published studies support these results. A literature search of PubMed, Embase, Medline, and the Cochrane Library up until September 2016 identified 17 studies suitable for further investigation. A meta-analysis was conducted on these studies to investigate the association between serum selenium levels and subsequent prostate cancer risk. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the overall OR of prostate cancer for the highest versus the lowest levels of serum selenium. We found a pooled OR (95% CI) of 0.76 (0.64, 0.91; P |
| doi_str_mv | 10.1097/MD.0000000000005944 |
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A literature search of PubMed, Embase, Medline, and the Cochrane Library up until September 2016 identified 17 studies suitable for further investigation. A meta-analysis was conducted on these studies to investigate the association between serum selenium levels and subsequent prostate cancer risk. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the overall OR of prostate cancer for the highest versus the lowest levels of serum selenium. We found a pooled OR (95% CI) of 0.76 (0.64, 0.91; P < 0.05). In subgroup analysis, an inverse association between serum selenium levels and prostate cancer risk was found in each of case-control studies, current and former smokers, high-grade cancer cases, advanced cancer cases, and different populations. Such correlations were not found for subgroups containing each of cohort studies, nonsmokers, low-grade cancer cases, and early stage cancer cases. In conclusion, our study suggests an inverse relationship between serum selenium levels and prostate cancer risk. However, further cohort studies and randomized control trials based on non-Western populations are required.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000005944</identifier><identifier>PMID: 28151881</identifier><language>eng</language><publisher>United States: The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Biomarkers, Tumor ; Humans ; Male ; Meta-Analysis of Observational Studies in Epidemiology ; Neoplasm Grading ; Neoplasm Staging ; Observational Studies as Topic ; Odds Ratio ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - epidemiology ; Risk Factors ; Selenium - blood ; Smoking - epidemiology</subject><ispartof>Medicine (Baltimore), 2017-02, Vol.96 (5), p.e5944-e5944</ispartof><rights>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2855-262b48f1f039506e7078ae91be343169b27312548bb690335192ce4ae30eca093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293444/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293444/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28151881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cui, Zhigang</creatorcontrib><creatorcontrib>Liu, Dezhong</creatorcontrib><creatorcontrib>Liu, Chun</creatorcontrib><creatorcontrib>Liu, Gang</creatorcontrib><title>Serum selenium levels and prostate cancer risk: A MOOSE-compliant meta-analysis</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Some observational studies have shown that elevated serum selenium levels are associated with reduced prostate cancer risk; however, not all published studies support these results. A literature search of PubMed, Embase, Medline, and the Cochrane Library up until September 2016 identified 17 studies suitable for further investigation. A meta-analysis was conducted on these studies to investigate the association between serum selenium levels and subsequent prostate cancer risk. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the overall OR of prostate cancer for the highest versus the lowest levels of serum selenium. We found a pooled OR (95% CI) of 0.76 (0.64, 0.91; P < 0.05). In subgroup analysis, an inverse association between serum selenium levels and prostate cancer risk was found in each of case-control studies, current and former smokers, high-grade cancer cases, advanced cancer cases, and different populations. Such correlations were not found for subgroups containing each of cohort studies, nonsmokers, low-grade cancer cases, and early stage cancer cases. In conclusion, our study suggests an inverse relationship between serum selenium levels and prostate cancer risk. However, further cohort studies and randomized control trials based on non-Western populations are required.</description><subject>Biomarkers, Tumor</subject><subject>Humans</subject><subject>Male</subject><subject>Meta-Analysis of Observational Studies in Epidemiology</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Staging</subject><subject>Observational Studies as Topic</subject><subject>Odds Ratio</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - epidemiology</subject><subject>Risk Factors</subject><subject>Selenium - blood</subject><subject>Smoking - epidemiology</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUctOxDAMjBAIlscXIKEeuQScV9NwQELLU2K1B-AcpcHLFtJ2SVoQf09hAQG-2LLHY2uGkF0GBwyMPpycHsCvUEbKFTJiSuRUmVyukhEAV1QbLTfIZkqPAExoLtfJBi-YYkXBRmR6g7Gvs4QBm2ooAr5gSJlr7rNFbFPnOsy8azzGLFbp6Sg7ySbT6c0Z9W29CJVruqzGzlHXuPCWqrRN1mYuJNz5ylvk7vzsdnxJr6cXV-OTa-p5oRTlOS9lMWMzEEZBjhp04dCwEoUULDcl14JxJYuyzA0IoZjhHqVDAegdGLFFjpe8i76s8d5j00UX7CJWtYtvtnWV_Ttpqrl9aF-s4kZIKQeC_S-C2D73mDpbV8ljCK7Btk-WFbkaNJKaD1CxhPpBkRRx9nOGgf2wwk5O7X8rhq293x_-7HxrPwDkEvDahg5jegr9K0Y7Rxe6-Sef0oZTDkwDBwF06Agl3gHzsZL5</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Cui, Zhigang</creator><creator>Liu, Dezhong</creator><creator>Liu, Chun</creator><creator>Liu, Gang</creator><general>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170201</creationdate><title>Serum selenium levels and prostate cancer risk: A MOOSE-compliant meta-analysis</title><author>Cui, Zhigang ; Liu, Dezhong ; Liu, Chun ; Liu, Gang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2855-262b48f1f039506e7078ae91be343169b27312548bb690335192ce4ae30eca093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Biomarkers, Tumor</topic><topic>Humans</topic><topic>Male</topic><topic>Meta-Analysis of Observational Studies in Epidemiology</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Staging</topic><topic>Observational Studies as Topic</topic><topic>Odds Ratio</topic><topic>Prostatic Neoplasms - blood</topic><topic>Prostatic Neoplasms - epidemiology</topic><topic>Risk Factors</topic><topic>Selenium - blood</topic><topic>Smoking - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cui, Zhigang</creatorcontrib><creatorcontrib>Liu, Dezhong</creatorcontrib><creatorcontrib>Liu, Chun</creatorcontrib><creatorcontrib>Liu, Gang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cui, Zhigang</au><au>Liu, Dezhong</au><au>Liu, Chun</au><au>Liu, Gang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum selenium levels and prostate cancer risk: A MOOSE-compliant meta-analysis</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>96</volume><issue>5</issue><spage>e5944</spage><epage>e5944</epage><pages>e5944-e5944</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Some observational studies have shown that elevated serum selenium levels are associated with reduced prostate cancer risk; however, not all published studies support these results. A literature search of PubMed, Embase, Medline, and the Cochrane Library up until September 2016 identified 17 studies suitable for further investigation. A meta-analysis was conducted on these studies to investigate the association between serum selenium levels and subsequent prostate cancer risk. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the overall OR of prostate cancer for the highest versus the lowest levels of serum selenium. We found a pooled OR (95% CI) of 0.76 (0.64, 0.91; P < 0.05). In subgroup analysis, an inverse association between serum selenium levels and prostate cancer risk was found in each of case-control studies, current and former smokers, high-grade cancer cases, advanced cancer cases, and different populations. Such correlations were not found for subgroups containing each of cohort studies, nonsmokers, low-grade cancer cases, and early stage cancer cases. In conclusion, our study suggests an inverse relationship between serum selenium levels and prostate cancer risk. However, further cohort studies and randomized control trials based on non-Western populations are required.</abstract><cop>United States</cop><pub>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>28151881</pmid><doi>10.1097/MD.0000000000005944</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wolters Kluwer Open Health; IngentaConnect Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Biomarkers, Tumor Humans Male Meta-Analysis of Observational Studies in Epidemiology Neoplasm Grading Neoplasm Staging Observational Studies as Topic Odds Ratio Prostatic Neoplasms - blood Prostatic Neoplasms - epidemiology Risk Factors Selenium - blood Smoking - epidemiology |
| title | Serum selenium levels and prostate cancer risk: A MOOSE-compliant meta-analysis |
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