Serum selenium levels and prostate cancer risk: A MOOSE-compliant meta-analysis

Some observational studies have shown that elevated serum selenium levels are associated with reduced prostate cancer risk; however, not all published studies support these results. A literature search of PubMed, Embase, Medline, and the Cochrane Library up until September 2016 identified 17 studies...

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Veröffentlicht in:	Medicine (Baltimore) 2017-02, Vol.96 (5), p.e5944-e5944
Hauptverfasser:	Cui, Zhigang, Liu, Dezhong, Liu, Chun, Liu, Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor Humans Male Meta-Analysis of Observational Studies in Epidemiology Neoplasm Grading Neoplasm Staging Observational Studies as Topic Odds Ratio Prostatic Neoplasms - blood Prostatic Neoplasms - epidemiology Risk Factors Selenium - blood Smoking - epidemiology
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Zusammenfassung:	Some observational studies have shown that elevated serum selenium levels are associated with reduced prostate cancer risk; however, not all published studies support these results. A literature search of PubMed, Embase, Medline, and the Cochrane Library up until September 2016 identified 17 studies suitable for further investigation. A meta-analysis was conducted on these studies to investigate the association between serum selenium levels and subsequent prostate cancer risk. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the overall OR of prostate cancer for the highest versus the lowest levels of serum selenium. We found a pooled OR (95% CI) of 0.76 (0.64, 0.91; P
ISSN:	0025-7974 1536-5964
DOI:	10.1097/MD.0000000000005944