Accelerated burn wound closure in mice with a new formula based on traditional medicine
Background : A combination of the oils of sesame, hemp, wild pistachio, and walnut has been used for treatment of skin disorders, including wound burns, in some parts of Kerman, Iran. Evaluation of this remedy in the form of a pharmaceutical formulation in animal models can pave the way for its futu...
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Veröffentlicht in: | Iranian red crescent medical journal 2016-11, Vol.18 (11), p.1-9 |
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Sprache: | eng |
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Zusammenfassung: | Background : A combination of the oils of sesame, hemp, wild pistachio, and walnut has been used for treatment of skin disorders,
including wound burns, in some parts of Kerman, Iran. Evaluation of this remedy in the form of a pharmaceutical formulation in
animal models can pave the way for its future application in wound burn healing in humans.
Objectives : This experimental study investigated the healing potential of a new formula (NF) based on folk medicine from Iran for
the treatment of third degree burns in mice. The formula was a combination of the oils of four plants: sesame (Sesamum indicum L.),
wild pistachio (Pistacia atlantica Desf.), hemp (Cannabis sativa L.), and walnut (Juglans regia L.)
Methods : Twenty-four mice were selected based on simple random sampling. Twenty-five percent of the total body surface area was
burned by exposure to boiling water, according to theWalker-Mason method. NF and silver sulfadiazine (the positive control) were
applied topically twice a day for 21 days. The burned area in the negative control group was left untreated. Epithelialization time
and the percent of wound contraction were measured during the treatment period. The process of wound repairing was evaluated
using histological (H and E and trichrome staining) and immunohistological (anti-pancytokeratin) methods.
Results: Whencompared to the controls, NF significantly improvedwoundcontraction after day 10. Epithelialization time in the NF
group was significantly faster than in the other groups (20 vs. 25.5 days) (P < 0.001). Histopathological and immunohistochemical
findings confirmed the efficacy of the NF.
Conclusions : A new therapeutic remedy was introduced for the treatment of burn wounds. Further clinical and molecular studies
are suggested to determine the exact mechanism(s) involved in the burn wound healing effect of NF. |
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ISSN: | 2074-1804 2074-1812 |
DOI: | 10.5812/ircmj.26613 |