Engineered Nano-Platelets for Enhanced Treatment of Multiple Myeloma and Thrombus

Engineered Nano-Platelets for Enhanced Treatment of Multiple Myeloma and Thrombus

A platelet membrane-coated biomimetic nanocarrier, which could sequentially target bone microenvironment and myeloma cells to enhance the drug availability at the myeloma site and decrease the off-target effects, was developed for inhibiting the multiple myeloma growth and simultaneously eradicating...

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Veröffentlicht in:Advanced materials (Weinheim) 2016-09, Vol.28 (43), p.9573-9580
Hauptverfasser: Hu, Quanyin, Qian, Chenggen, Sun, Wujin, Wang, Jinqiang, Chen, Zhaowei, Bomba, Hunter N., Xin, Hongliang, Shen, Qundong, Gu, Zhen
Format: Artikel
Sprache:eng
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Zusammenfassung:A platelet membrane-coated biomimetic nanocarrier, which could sequentially target bone microenvironment and myeloma cells to enhance the drug availability at the myeloma site and decrease the off-target effects, was developed for inhibiting the multiple myeloma growth and simultaneously eradicating the thrombus complication.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201603463