The Prognostic Role of NEDD9 and P38 Protein Expression Levels in Urinary Bladder Transitional Cell Carcinoma

The Prognostic Role of NEDD9 and P38 Protein Expression Levels in Urinary Bladder Transitional Cell Carcinoma

Background. The most common malignant tumor of the urinary bladder is transitional cell carcinoma (TCC). Neural precursor cell-expressed developmentally downregulated protein 9 (NEDD9) is found to be a cell adhesion mediator. P38 Mitogen-Activated Protein Kinase is a serine/threonine kinases member...

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Veröffentlicht in:Journal of Oncology 2017-01, Vol.2017 (2017), p.1-9-006
Hauptverfasser: Abdel Wahab, Khaled M., Abdelaziz, Lobna A., Abdelbary, Abeer M., El Shorbagy, Shereen, Ali, Maged M., Haggag, Rasha, Harb, Ola A., Salim, Reham A.
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies
Bladder cancer
Cell adhesion & migration
Cell cycle
Cloning
Gene expression
Genetic aspects
Kinases
Lymphatic system
Males
Medical prognosis
Metastasis
Physiological aspects
Prognosis
Protein kinases
Proteins
Tumors
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Zusammenfassung:Background. The most common malignant tumor of the urinary bladder is transitional cell carcinoma (TCC). Neural precursor cell-expressed developmentally downregulated protein 9 (NEDD9) is found to be a cell adhesion mediator. P38 Mitogen-Activated Protein Kinase is a serine/threonine kinases member which can mediate carcinogenesis through intracellular signaling. Methods. To assess their prognostic role; NEDD9 and p38 protein were evaluated in sections from 50 paraffin blocks of TCC. Results. The high expressions of NEDD9 and p38 protein were significantly associated with grade, stage, distant metastasis (p
ISSN:1687-8450
1687-8450
DOI:10.1155/2017/6095205