Passive antibodies derived from intramuscularly immunized toxoid fusion 3xSTaN12S -dmLT protect against STa+ enterotoxigenic Escherichia coli (ETEC) diarrhea in a pig model

Passive antibodies derived from intramuscularly immunized toxoid fusion 3xSTaN12S -dmLT protect against STa+ enterotoxigenic Escherichia coli (ETEC) diarrhea in a pig model

Highlights • Toxoid fusion 3xSTaN12S -dmLT induces neutralizing antibodies in IM immunized pigs. • Passive acquired antibodies protect piglets against STa ETEC diarrhea. • A pig challenge mode is ideal for ETEC antitoxin vaccines.

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Bibliographische Detailangaben
Veröffentlicht in:Vaccine 2017-01, Vol.35 (4), p.552-556
Hauptverfasser: Nandre, Rahul M, Duan, Qiangde, Wang, Yin, Zhang, Weiping
Format: Artikel
Sprache:eng
Schlagworte:
3xSTaN12S-dmLT
Allergy and Immunology
antibodies
Antitoxins
children
Conflicts of interest
Diarrhea
E coli
enterotoxigenic Escherichia coli
Enterotoxigenic Escherichia coli (ETEC)
Escherichia coli
gilts
heat stability
Hogs
Immunization
immunoglobulin A
immunoglobulin G
mice
neutralization
Pig challenge model
piglets
suckling
Toxins
Toxoid fusion
Vaccine
vaccine development
Vaccines
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Beschreibung
Zusammenfassung:Highlights • Toxoid fusion 3xSTaN12S -dmLT induces neutralizing antibodies in IM immunized pigs. • Passive acquired antibodies protect piglets against STa ETEC diarrhea. • A pig challenge mode is ideal for ETEC antitoxin vaccines.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2016.12.021