Gender-specific differences in hypothalamus-pituitary-adrenal axis activity during childhood: a systematic review and meta-analysis

Gender-specific differences in hypothalamus-pituitary-adrenal axis activity during childhood: a systematic review and meta-analysis

Gender-specific differences in hypothalamus-pituitary-adrenal (HPA) axis activity have been postulated to emerge during puberty. We conducted a systematic review and meta-analysis to test the hypothesis that gender-specific differences in HPA axis activity are already present in childhood. From ince...

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Veröffentlicht in:Biology of sex differences 2017-01, Vol.8 (1), p.3-3, Article 3
Hauptverfasser: van der Voorn, Bibian, Hollanders, Jonneke J, Ket, Johannes C F, Rotteveel, Joost, Finken, Martijn J J
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Child
Humans
Hypothalamic-pituitary-adrenal axis
Hypothalamo-Hypophyseal System - physiology
Pituitary-Adrenal System - physiology
Puberty
Review
Sex Characteristics
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Zusammenfassung:Gender-specific differences in hypothalamus-pituitary-adrenal (HPA) axis activity have been postulated to emerge during puberty. We conducted a systematic review and meta-analysis to test the hypothesis that gender-specific differences in HPA axis activity are already present in childhood. From inception to January 2016, PubMed and EMBASE.com were searched for studies that assessed non-stimulated cortisol in serum or saliva or cortisol in 24-h urine in healthy males and females aged ≤18 years. Studies that conform with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement were reported. Standardized mean differences (95% CIs) were calculated and analyzed using fixed-effect meta-analysis stratified for age:
ISSN:2042-6410
2042-6410
DOI:10.1186/s13293-016-0123-5