High phenolics Rutgers Scarlet Lettuce improves glucose metabolism in high fat diet-induced obese mice

Scope The ability of high phenolic Rutgers Scarlet Lettuce (RSL) to attenuate metabolic syndrome and gut dysbiosis was studied in very high fat diet (VHFD)‐fed mice. Phenolic absorption was assessed in vivo and in a gastrointestinal tract model. Methods and results Mice were fed VHFD, VHFD supplemen...

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Veröffentlicht in:	Molecular nutrition & food research 2016-11, Vol.60 (11), p.2367-2378
Hauptverfasser:	Cheng, Diana M., Roopchand, Diana E., Poulev, Alexander, Kuhn, Peter, Armas, Isabel, Johnson, William D., Oren, Andrew, Ribnicky, David, Zelzion, Ehud, Bhattacharya, Debashish, Raskin, Ilya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioaccessibility Carbohydrate Metabolism Diet, Fat-Restricted Diet, High-Fat - adverse effects Dietary Fats - metabolism Gastrointestinal Tract - microbiology Glucose - metabolism Glucose Tolerance Test Gut microbiota Hyperglycemia - metabolism Lactuca - chemistry Lettuce Liver - metabolism Male Metabolic syndrome Metabolic Syndrome - metabolism Mice Mice, Inbred C57BL Mice, Obese Obesity - metabolism Phenolics Quercetin - analogs & derivatives Triglycerides - metabolism Weight Gain
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Zusammenfassung:	Scope The ability of high phenolic Rutgers Scarlet Lettuce (RSL) to attenuate metabolic syndrome and gut dysbiosis was studied in very high fat diet (VHFD)‐fed mice. Phenolic absorption was assessed in vivo and in a gastrointestinal tract model. Methods and results Mice were fed VHFD, VHFD supplemented with RSL (RSL‐VHFD) or store‐purchased green lettuce (GL‐VHFD), or low‐fat diet (LFD) for 13 weeks. Compared to VHFD or GL‐VHFD‐fed groups, RSL‐VHFD group showed significantly improved oral glucose tolerance (p
ISSN:	1613-4125 1613-4133
DOI:	10.1002/mnfr.201600290