Dysregulation of MALAT1 and miR-619-5p as a prognostic indicator in advanced colorectal carcinoma

The present study aimed to detect the expression of metastasis associated lung adenocarcinoma transcript 1 (MALAT1) and microRNA (miR)-619-5p in colorectal carcinoma (CRC), and to evaluate the significance of MALAT1 and miR-619-5p expression in the clinical diagnosis and prognosis of CRC. Quantitati...

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Veröffentlicht in:	Oncology letters 2016-12, Vol.12 (6), p.5036-5042
Hauptverfasser:	Qiu, Gu, Zhang, Xiu-Bing, Zhang, Shu-Qing, Liu, Pei-Long, Wu, Wei, Zhang, Jin-Ye, Dai, Shi-Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Biotechnology Care and treatment Colorectal cancer colorectal carcinoma Diagnosis Gender Histology Lung cancer MALAT1 Medical prognosis Metastasis MicroRNA MicroRNAs miR-619-5p Polymerase chain reaction Prognosis prognostic indicator Statistical analysis Studies Surgery Tumorigenesis Tumors
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Zusammenfassung:	The present study aimed to detect the expression of metastasis associated lung adenocarcinoma transcript 1 (MALAT1) and microRNA (miR)-619-5p in colorectal carcinoma (CRC), and to evaluate the significance of MALAT1 and miR-619-5p expression in the clinical diagnosis and prognosis of CRC. Quantitative polymerase chain reaction was used to detect MALAT1 and miR-619-5p expression in 120 colorectal carcinoma and 120 adjacent normal tissue samples. The expression levels of MALAT1 and miR-619-5p were significantly different between colorectal carcinoma and adjacent normal tissues (P
ISSN:	1792-1074 1792-1082
DOI:	10.3892/ol.2016.5312