Epidermal growth factor receptor mutation enhances expression of vascular endothelial growth factor in lung cancer

Epidermal growth factor receptor mutation enhances expression of vascular endothelial growth factor in lung cancer

Epidermal growth factor receptor (EGFR) activation has been demonstrated to have a critical role in tumor angiogenesis. In the present study, the correlation between EGFR mutations and vascular endothelial growth factor (VEGF) was investigated in lung cancer cell lines and non-small-cell lung cancer...

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Veröffentlicht in:Oncology letters 2016-12, Vol.12 (6), p.4598-4604
Hauptverfasser: Hung, Ming-Szu, Chen, I-Chuan, Lin, Paul-Yann, Lung, Jr-Hau, Li, Ya-Chin, Lin, Yu-Ching, Yang, Cheng-Ta, Tsai, Ying-Huang
Format: Artikel
Sprache:eng
Schlagworte:
Care and treatment
Development and progression
Epidermal growth factor
erpidermal growth factor receptor
Gene expression
Gene mutations
Genetic aspects
Health aspects
Kinases
Laboratories
Lung cancer
Mutation
Oncology
vascular endothelial growth factor
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Zusammenfassung:Epidermal growth factor receptor (EGFR) activation has been demonstrated to have a critical role in tumor angiogenesis. In the present study, the correlation between EGFR mutations and vascular endothelial growth factor (VEGF) was investigated in lung cancer cell lines and non-small-cell lung cancer (NSCLC) tumor tissues. VEGF levels were significantly increased in culture medium of lung cancer cells and NSCLC tissues with EGFR mutations (H1650 vs. A549, P=0.0399; H1975 vs. A549, P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2016.5287